Kiecker Clemens, Lumsden Andrew
MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.
F1000 Biol Rep. 2009 Jan 21;1:1. doi: 10.3410/B1-1.
A surprisingly small number of signalling pathways are used reiteratively during neural development, eliciting very different responses depending on the cellular context. Thus, the way a neural cell responds to a given signal is as important as the signal itself and this responsiveness, also called competence, changes with time. Here we describe recent advances in elucidating the signalling pathways that operate in brain development.
在神经发育过程中,数量惊人少的信号通路被反复使用,根据细胞环境引发非常不同的反应。因此,神经细胞对给定信号的反应方式与信号本身同样重要,而且这种反应能力,也称为感受态,会随时间变化。在这里,我们描述了在阐明大脑发育中起作用的信号通路方面的最新进展。