Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK
Development. 2019 Sep 16;146(18):dev167106. doi: 10.1242/dev.167106.
The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a 'jack of all trades' that is reiteratively used to mediate a range of cellular decision-making processes from proliferation, death and morphogenesis to cell fate determination. Here, and in the accompanying poster, we briefly outline the core pathway and its regulation, and describe the breadth of its roles in animal development.
Hippo 信号通路及其转录共激活因子靶标 Yorkie/YAP/TAZ 最初因其在组织生长控制中的作用而受到关注。在过去的 15 年中，很明显，像其他发育途径（例如 Wnt、Hedgehog 和 TGFβ 途径）一样，Hippo 信号是一种“多面手”，它被反复用于介导一系列细胞决策过程，从增殖、死亡和形态发生到细胞命运决定。在这里，以及在配套的海报中，我们简要概述了核心途径及其调节，并描述了它在动物发育中的广泛作用。
