Geboes Karel, Geboes Karen P
F1000 Med Rep. 2009 Apr 29;1:32. doi: 10.3410/M1-32.
It is now clearly established that coeliac disease is much more common than originally considered. While in the past it was taught that coeliac disease was mainly a disease of children, it is clear now that it may be diagnosed at any age. The clinical presentation of adolescents and adults is, however, less typical. Recent evidence suggests that coeliac disease is a multi-organ disease. The diagnostic techniques involving histology and serologic testing have been improved and the involvement of environmental and genetic factors in the pathogenesis of this immune disorder has been clarified, although the pathogenesis is not yet completely understood. Complications are now better identified, and new treatment strategies are under consideration.
现在已经明确，乳糜泻比最初认为的要常见得多。过去认为乳糜泻主要是儿童疾病，但现在很清楚，它在任何年龄都可能被诊断出来。然而，青少年和成人的临床表现不太典型。最近的证据表明，乳糜泻是一种多器官疾病。涉及组织学和血清学检测的诊断技术已经得到改进，环境和遗传因素在这种免疫紊乱发病机制中的作用也已得到阐明，尽管发病机制尚未完全了解。现在对并发症有了更好的认识，并且正在考虑新的治疗策略。
