新生朊病毒
De novo prions.
作者信息
Benetti Federico, Geschwind Michael D, Legname Giuseppe
出版信息
F1000 Biol Rep. 2010 Jun 23;2:46. doi: 10.3410/B2-46.
Abstract
Prions are responsible for a heterogeneous group of fatal neurodegenerative diseases. They occur in three forms - sporadic, genetic, or acquired - and involve non-covalent post-translational modifications of the cellular prion protein (PrP(C)). Prions (PrP(Sc)) are characterized by their infectious properties and intrinsic ability to act as a template, converting the normal, physiological PrP(C) into the pathological form, PrP(Sc). The 'protein-only' hypothesis, postulated by Stanley B Prusiner, implies that the generation of de novo prions is possible. Exciting recent work, in vivo and in vitro, has further strengthened this postulate.
摘要
朊病毒是导致一组异质性致命神经退行性疾病的病原体。它们以三种形式出现——散发性、遗传性或获得性——并涉及细胞朊蛋白（PrP(C)）的非共价翻译后修饰。朊病毒（PrP(Sc)）的特征在于其传染性以及作为模板将正常的生理性PrP(C)转化为病理性形式PrP(Sc)的内在能力。由斯坦利·B·普鲁西纳提出的“仅蛋白质”假说是指有可能从头产生朊病毒。近期令人振奋的体内和体外研究工作进一步强化了这一假说。
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Acta Neuropathol. 2010 Feb;119(2):177-87. doi: 10.1007/s00401-009-0633-x. Epub 2010 Jan 6.
4
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Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20417-22. doi: 10.1073/pnas.0910350106. Epub 2009 Nov 13.
5
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6
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7
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8
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