疟原虫中脂肪酸摄取与代谢的最新见解。
Recent insights into fatty acid acquisition and metabolism in malarial parasites.
作者信息
Jayabalasingham Bamini, Menard Robert, Fidock David A
出版信息
F1000 Biol Rep. 2010 Mar 25;2:24. doi: 10.3410/B2-24.
Abstract
The malarial parasite has a tremendous requirement for fatty acids during the replicative stages that take place in the mammalian host. A series of recent papers, discussed below, have revealed some of the mechanisms employed by the parasite to meet these demands.
摘要
疟原虫在哺乳动物宿主体内进行复制的阶段对脂肪酸有极大的需求。如下所讨论的，最近的一系列论文揭示了疟原虫为满足这些需求所采用的一些机制。
相似文献
1
Recent insights into fatty acid acquisition and metabolism in malarial parasites.疟原虫中脂肪酸摄取与代谢的最新见解。
F1000 Biol Rep. 2010 Mar 25;2:24. doi: 10.3410/B2-24.
2
Variations in structure and function during the life cycle of malarial parasites.疟原虫生命周期中结构和功能的变化。
Bull World Health Organ. 1977;55(2-3):139-56.
3
Comprehensive Characterization of Acyl Coenzyme A-Binding Protein TgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism.酰基辅酶 A 结合蛋白 TgACBP2 的全面表征及其在寄生虫心磷脂代谢中的关键作用。
mBio. 2018 Oct 23;9(5):e01597-18. doi: 10.1128/mBio.01597-18.
4
FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS.疟原虫血症和三日疟原虫寄生虫迁移对疟疾寄生虫的影响。
J Exp Med. 1914 Jun 1;19(6):523-35. doi: 10.1084/jem.19.6.523.
5
Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling.顶复门寄生虫的分裂和对宿主环境的适应依赖于质体脂质代谢的可塑性和宿主细胞器的重塑。
Cell Rep. 2020 Mar 17;30(11):3778-3792.e9. doi: 10.1016/j.celrep.2020.02.072.
6
Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives.通过靶向顶质体进行抗疟药物设计：新视角
J Pharmacopuncture. 2016 Mar;19(1):7-15. doi: 10.3831/KPI.2016.19.001.
7
Melatonin effects on Plasmodium life cycle: new avenues for therapeutic approach.褪黑素对疟原虫生命周期的影响：治疗方法的新途径。
Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):139-47. doi: 10.2174/187221412800604635.
8
Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.恶性疟原虫和伯氏疟原虫甘油-3-磷酸酰基转移酶的特性研究，该酶参与疟原虫顶质体中II型脂肪酸合成途径的脂肪酸利用过程。
Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12633. Epub 2016 Aug 1.
9
Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay.使用一种简单可靠的体外寄生虫活力快速测定法来鉴定快速杀寄生虫的抗疟药物。
Malar J. 2015 Nov 5;14:441. doi: 10.1186/s12936-015-0962-2.
10
Parasite Sensing of Host Nutrients and Environmental Cues.寄生虫感知宿主营养物质和环境线索。
Cell Host Microbe. 2018 Jun 13;23(6):749-758. doi: 10.1016/j.chom.2018.05.018.
引用本文的文献
1
M--M mediated denaturation resistant P2 tetramer on the infected erythrocyte surface of malaria parasite imports serum fatty acids.疟原虫感染红细胞表面的M介导的抗变性P2四聚体可导入血清脂肪酸。
iScience. 2024 Apr 16;27(5):109760. doi: 10.1016/j.isci.2024.109760. eCollection 2024 May 17.
2
Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.急性疟疾与慢性疟疾的特征在于不同的氨基酸和脂质变化。
JCI Insight. 2019 May 2;4(9). doi: 10.1172/jci.insight.125156.
3
Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia.载脂蛋白 E 基因与血红蛋白 S 基因的上位性相互作用对疟疾寄生虫血症的调节。
PLoS One. 2013 Oct 8;8(10):e76924. doi: 10.1371/journal.pone.0076924. eCollection 2013.
本文引用的文献
1
Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection.疟原虫丙酮酸脱氢酶的活性对寄生虫从肝脏感染到血液感染的过程是必需的。
Mol Microbiol. 2010 Feb;75(4):957-71. doi: 10.1111/j.1365-2958.2009.07034.x.
2
Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.恶性疟原虫中油酸的生物合成：硬脂酰辅酶A去饱和酶的特性及作为潜在治疗靶点的研究
PLoS One. 2009 Sep 3;4(9):e6889. doi: 10.1371/journal.pone.0006889.
3
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development.II型脂肪酸合成仅对疟原虫肝脏晚期发育至关重要。
Cell Microbiol. 2009 Mar;11(3):506-20. doi: 10.1111/j.1462-5822.2008.01270.x. Epub 2008 Dec 3.
4
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.脂肪酸生物合成酶FabI在肝期疟原虫的发育中起关键作用。
Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001.
5
Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection.清道夫受体BI增强肝细胞对疟原虫感染的易感性。
Cell Host Microbe. 2008 Sep 11;4(3):283-92. doi: 10.1016/j.chom.2008.07.013.
6
Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection.宿主清道夫受体SR-BI在疟原虫肝脏感染的建立过程中发挥双重作用。
Cell Host Microbe. 2008 Sep 11;4(3):271-82. doi: 10.1016/j.chom.2008.07.012.
7
Crystal structure of soluble domain of malaria sporozoite protein UIS3 in complex with lipid.疟原虫子孢子蛋白UIS3可溶性结构域与脂质复合物的晶体结构
J Biol Chem. 2008 Aug 29;283(35):24077-88. doi: 10.1074/jbc.M801946200. Epub 2008 Jun 23.
8
A combined transcriptome and proteome survey of malaria parasite liver stages.疟原虫肝脏期的转录组和蛋白质组联合研究。
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):305-10. doi: 10.1073/pnas.0710780104. Epub 2008 Jan 2.
9
Distinct physiological states of Plasmodium falciparum in malaria-infected patients.疟疾感染患者体内恶性疟原虫的不同生理状态。
Nature. 2007 Dec 13;450(7172):1091-5. doi: 10.1038/nature06311. Epub 2007 Nov 28.
10
Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum.油酸对于恶性疟原虫在红细胞内的增殖是必不可少的。
Parasitology. 2007 Nov;134(Pt 12):1671-7. doi: 10.1017/S0031182007003137. Epub 2007 Jul 5.
Zotero 插件