抗原受体基因重排的表观遗传调控。
Epigenetic regulation of antigen receptor gene rearrangement.
作者信息
Spicuglia Salvatore, Zacarias-Cabeza Joaquin, Pekowska Aleksandra, Ferrier Pierre
出版信息
F1000 Biol Rep. 2010 Mar 25;2:23. doi: 10.3410/B2-23.
Abstract
V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination.
摘要
V(D)J重排过程在淋巴细胞发育期间，从种系V、D和J基因片段组装抗原特异性免疫球蛋白和T细胞受体可变区基因。该位点特异性DNA重排过程的调控涉及细胞类型和分化阶段、基因座重排顺序以及等位基因使用情况。其中许多调控是通过调节V(D)J重组酶对基因的可及性来介导的。在此，我们总结了有关核组织和基于表观遗传学的机制对V(D)J重排调控影响的最新进展。
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