Dunnett S B
Department of Experimental Psychology, University of Cambridge, UK.
Prog Brain Res. 1990;85:285-96; discussion 296-7. doi: 10.1016/s0079-6123(08)62685-0.
The techniques are now well established for the viable transplantation of cortical and other neural tissues into the neonatal and adult cortex, at least in the laboratory rat. Under appropriate conditions such grafts survive well and can establish reciprocal connections with the host brain. On this basis, neural transplantation has become a powerful technique for the study of mechanisms involved in the development of the central nervous system and its capacity for regeneration after injury. Moreover, a variety of anatomical, electrophysiological and behavioural techniques suggest that grafted neural tissue may sustain functional interactions with the host brain. However, the extent and duration of recovery using present techniques is extremely limited. It remains undetermined whether such experimental observations may ever acquire therapeutic application.
至少在实验大鼠中，将皮质及其他神经组织有效移植到新生和成年皮质的技术现已成熟。在适当条件下，此类移植物存活良好，并能与宿主脑建立相互连接。在此基础上，神经移植已成为研究中枢神经系统发育机制及其损伤后再生能力的有力技术。此外，各种解剖学、电生理学和行为学技术表明，移植的神经组织可能与宿主脑维持功能相互作用。然而，使用现有技术恢复的程度和持续时间极其有限。此类实验观察结果是否能获得治疗应用仍未确定。
