Radil-Weiss T
Act Nerv Super (Praha). 1975 Mar;17(1):15-9.
Rats were deprived of sleep by placing them for 36 hours in a slowly moving drum. After this procedure, during recovery sleep, the latency of onset of the first rhombencephalic - paradoxical sleep period decreased and the proportion of telencephalic/rhombencephalic - slow wave sleep reversed (during the first hour of recovery sleep). Repeated administration during the deprivation period of physostigmine (0,5 mg/kg i. p. in 30 min intervals 20-30 times) inducing in waking animals in EEG pattern close to that of rhombencephalic sleep, or atropine (1 mg/kg i. p. in 60 min intervals 10-15 times) evoking an activity resembling telencephalic sleep, did not change the above measures of recovery sleep. Pharmacologically induced sleep-like patterns did not substitute for the sleep the rats were deprived off.
将大鼠置于缓慢移动的滚筒中36小时以剥夺其睡眠。在此过程之后，在恢复睡眠期间，首次后脑-异相睡眠期开始的潜伏期缩短，并且端脑/后脑-慢波睡眠的比例发生逆转（在恢复睡眠的第一小时内）。在剥夺期期间重复给予毒扁豆碱（0.5毫克/千克腹腔注射，间隔30分钟，共20 - 30次），可使清醒动物的脑电图模式接近后脑睡眠，或给予阿托品（1毫克/千克腹腔注射，间隔60分钟，共10 - 15次），诱发类似端脑睡眠的活动，但并未改变上述恢复睡眠的指标。药理学诱导的睡眠样模式不能替代大鼠被剥夺的睡眠。
