Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., ML# 5031, Cincinnati, OH 45229, USA.
Pediatr Radiol. 2011 Mar;41(3):341-9. doi: 10.1007/s00247-010-1839-8. Epub 2010 Oct 15.
Focal nodular hyperplasia (FNH) is a benign hepatic tumor that is rare in children. In order to understand whether there are differences in the etiology or appearance of FNH in children, we analyzed the clinical information and imaging of pathologically proven cases.
A pathology database was used to identify all cases of FNH diagnosed at our institution. Each patient's imaging was evaluated for the characteristics of FNH lesions. Clinical information was obtained on each patient.
Thirteen patients with FNH were identified (7 male/6 female, mean age 14.3 years, range 1-27 years). Seven patients (5 male/2 female) had a remote history of childhood malignancy. The time interval between the diagnoses of malignancy and FNH ranged from 9 to 27 years (mean 14.4 years). On imaging, all seven cancer survivors had multiple liver lesions. In the remaining six patients (2 male/4 female), there was no history of malignancy and all but one of these patients had a solitary FNH.
Half of the patients with FNH in this study were long-term cancer survivors and each of these patients had multiple masses. Recognizing the features of FNH will aid in diagnosis and appropriate management.
局灶性结节性增生（FNH）是一种罕见于儿童的良性肝肿瘤。为了了解儿童 FNH 的病因或表现是否存在差异，我们分析了经病理证实的病例的临床信息和影像学表现。
利用病理学数据库确定了我院诊断的所有 FNH 病例。对每位患者的影像学检查结果进行了 FNH 病变特征评估。获取了每位患者的临床信息。
共发现 13 例 FNH 患者（7 例男性/6 例女性，平均年龄 14.3 岁，范围 1-27 岁）。7 例患者（5 例男性/2 例女性）有儿童期恶性肿瘤的既往病史。恶性肿瘤和 FNH 的诊断间隔时间为 9-27 年（平均 14.4 年）。影像学检查上，7 例癌症幸存者均有多个肝脏病变。在其余 6 例患者（2 例男性/4 例女性）中，无恶性肿瘤病史，除 1 例外，其余均为单发 FNH。
本研究中一半的 FNH 患者为长期癌症幸存者，且每位患者均有多发性肿块。认识到 FNH 的特征将有助于诊断和适当的管理。
