Gutweiler Jordan R, Yu David C, Kim Heung B, Kozakewich Harry P, Marcus Karen J, Shamberger Robert C, Weldon Christopher B
Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
J Pediatr Surg. 2008 Dec;43(12):2297-300. doi: 10.1016/j.jpedsurg.2008.08.069.
Focal nodular hyperplasia (FNH) is a benign, poorly understood hepatic tumor that is rare in children. Although there is no evidence for malignant degeneration, FNH can occur adjacent to a malignancy. Here, the case of a 4-year-old boy with a hepatic mass and history of stage IV neuroblastoma is presented. Initial imaging and core-needle biopsy were consistent with FNH. However, after left lateral segmentectomy, pathologic examination revealed a malignant tumor most consistent with small cell undifferentiated hepatoblastoma as well as 3 foci of FNH in the surrounding parenchyma.
局灶性结节性增生（FNH）是一种良性但了解甚少的肝脏肿瘤，在儿童中较为罕见。虽然没有恶性变的证据，但FNH可发生于恶性肿瘤附近。本文报告1例4岁男性患儿，有肝脏肿块，曾患IV期神经母细胞瘤。初始影像学检查及粗针活检结果符合FNH。然而，在左外叶切除术后，病理检查显示为恶性肿瘤，最符合小细胞未分化型肝母细胞瘤，同时在周围实质内有3个FNH病灶。
