Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
Eur Arch Psychiatry Clin Neurosci. 2010 Nov;260 Suppl 2:S90-4. doi: 10.1007/s00406-010-0139-5. Epub 2010 Oct 14.
Indicated prevention is currently one of the most promising approaches to fight the individual and societal burden associated with psychosis and particularly schizophrenia. The number of studies is still limited, yet encouraging results have been reported from pharmacological and psychotherapeutic trials. Furthermore, it has become clear that persons characterized by the at-risk criteria are already ill and do not only need preventive intervention but also treatment. As is indicated by a recent study successfully using omega-3 fatty acids for both purposes, it may be promising to develop and investigate interventions especially for the at-risk state, independent of their effectiveness in manifest disease states. An overview on the current findings and ongoing research in this area is provided.
目前，有针对性的预防是对抗与精神病相关的个体和社会负担的最有前途的方法之一，尤其是精神分裂症。虽然相关研究的数量仍然有限，但已经有来自药理学和心理治疗试验的令人鼓舞的结果报告。此外，很明显，具有风险特征的人已经生病了，他们不仅需要预防干预，还需要治疗。最近的一项研究成功地使用ω-3 脂肪酸达到了这两个目的，这表明为有风险状态开发和研究干预措施可能是有前途的，而无需考虑它们在明显疾病状态下的有效性。本文就该领域的现有研究结果和正在进行的研究进行了综述。
