Burton M A, Kelleher D K, Codde J P, Gray B N
University of Western Australia, Department of Surgery, Royal Perth Hospital.
Sel Cancer Ther. 1990 Winter;6(4):177-82. doi: 10.1089/sct.1990.6.177.
The influence of regional liver hyperthermia in conjunction with systemic doxorubicin administration was examined in a rabbit VX2 tumour model. Hyperthermia was delivered by 2450MHz microwave generator to the exteriorised livers of the rabbits to provide a thermal dose equivalent of 43 degrees C for 30 minutes. Animals receiving doxorubicin infusion were treated with a total of 1.2 mg/kg over a 3 day protocol through an ear vein. Rabbits were divided into 4 groups; a no treatment control, hyperthermia alone, doxorubicin alone and hyperthermia immediately preceded by doxorubicin. The tumour mass, 10 days post treatment was significantly (P less than 0.0001) reduced in all treatment groups. However, the mean tumour mass in the combination treatment group was also significantly lower than both treatments alone (P less than 0.001). This increased response was not accompanied by any signs of increased systemic or local toxicity associated with any treatment.
在兔VX2肿瘤模型中研究了局部肝脏热疗联合全身给予阿霉素的影响。通过2450MHz微波发生器对兔的外置肝脏进行热疗，以提供相当于43℃持续30分钟的热剂量。接受阿霉素输注的动物在3天的方案中通过耳静脉共给予1.2mg/kg。将兔分为4组：无治疗对照组、单纯热疗组、单纯阿霉素组以及阿霉素后立即进行热疗组。治疗后10天，所有治疗组的肿瘤体积均显著（P<0.0001）减小。然而，联合治疗组的平均肿瘤体积也显著低于单独的两种治疗（P<0.001）。这种增强的反应并未伴随与任何治疗相关的全身或局部毒性增加的迹象。
