硬腭和上颌牙槽突鳞癌的区域性失败率较高。
High rates of regional failure in squamous cell carcinoma of the hard palate and maxillary alveolus.
机构信息
Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
出版信息
Head Neck. 2011 Jun;33(6):824-30. doi: 10.1002/hed.21547. Epub 2010 Oct 14.
Abstract
BACKGROUND
The purpose of this study was to determine the incidence of neck metastasis in hard palate and maxillary alveolus squamous cell carcinoma (SCC) and to identify factors predictive of regional failure.
METHODS
In 139 patients treated for SCC of the hard palate and maxillary alveolus (from 1985-2006), the incidence rates of regional metastasis at presentation and at recurrence were calculated. Factors predictive of regional recurrence-free survival were identified on Cox multivariable regression analysis.
RESULTS
Regional failure occurred in 28.4% of patients and was significantly associated with pathologic T classification, ranging from 18.7% (pT1) to 37.3% (pT4). T classification was an independent predictor of regional recurrence-free survival (RRFS) on multivariable analysis. Most patients (65.6%) with regional recurrence were not able to be salvaged.
CONCLUSION
Patients with T2 to T4 primary tumors of the hard palate and maxillary alveolus exhibited high rates of regional failure. In most cases, successful salvage was not achieved. Elective treatment of the neck with surgery or radiation is therefore recommended.
摘要
背景
本研究旨在确定硬腭和上颌牙槽突鳞状细胞癌（SCC）的颈部转移发生率，并确定局部复发的预测因素。
方法
对 139 例硬腭和上颌牙槽突 SCC 患者（1985 年至 2006 年）进行治疗，计算了局部转移在就诊时和复发时的发生率。使用 Cox 多变量回归分析确定了局部无复发生存的预测因素。
结果
28.4%的患者发生局部失败，与病理 T 分类显著相关，范围从 18.7%（pT1）到 37.3%（pT4）。T 分类是多变量分析中局部无复发生存的独立预测因素。大多数（65.6%）发生局部复发的患者无法挽救。
结论
硬腭和上颌牙槽突 T2 至 T4 期原发性肿瘤患者局部复发率较高。在大多数情况下，未能成功挽救。因此建议选择性进行手术或放疗治疗颈部。
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