Prasnikova G I, Iurkiv V A, Osipova N I, Sorochinskaia E P
Ter Arkh. 1990;62(11):22-5.
Patients with meningococcal infection, meningitis and with a mixed form of the disease were demonstrated to have unbalance in the redox system of glutathione during the all disease periods till the clinical recovery. Activation of glutathione peroxidases to hydrogen peroxide and tertiary butyl hydroperoxide in erythrocytes was coupled, during the whole disease, with unbalance of the time-course of changes in the interrelated enzymes--superoxide dismutase and glutathione peroxidase to hydrogen peroxide, while in neutrophils, the balance of those enzymes remained unimpaired. Glutathione transferase activity appeared reduced both in erythrocytes and neutrophils. Potential mechanisms by which the redox system of glutathione and superoxide dismutase may be deranged in meningococcal infection are under discussion.
患有脑膜炎球菌感染、脑膜炎以及混合形式疾病的患者，在整个疾病期间直至临床康复，其谷胱甘肽氧化还原系统均表现出失衡。在整个疾病过程中，红细胞中谷胱甘肽过氧化物酶对过氧化氢和叔丁基过氧化氢的激活，与相关酶——超氧化物歧化酶和谷胱甘肽过氧化物酶对过氧化氢变化的时间进程失衡相关联，而在中性粒细胞中，这些酶的平衡未受损害。谷胱甘肽转移酶活性在红细胞和中性粒细胞中均出现降低。目前正在讨论谷胱甘肽和超氧化物歧化酶氧化还原系统在脑膜炎球菌感染中可能发生紊乱的潜在机制。
