核体：粘性蛋白质的随机聚集体还是大分子组装的熔炉？
Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?
作者信息
Matera A Gregory, Izaguire-Sierra Mario, Praveen Kavita, Rajendra T K
机构信息
Departments of Biology and Genetics, Program in Molecular Biology and Biotechnology, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
出版信息
Dev Cell. 2009 Nov;17(5):639-47. doi: 10.1016/j.devcel.2009.10.017.
Abstract
The principles of self-assembly and self-organization are major tenets of molecular and cellular biology. Governed by these principles, the eukaryotic nucleus is composed of numerous subdomains and compartments, collectively described as nuclear bodies. Emerging evidence reveals that associations within and between various nuclear bodies and genomic loci are dynamic and can change in response to cellular signals. This review will discuss recent progress in our understanding of how nuclear body components come together, what happens when they form, and what benefit these subcellular structures may provide to the tissues or organisms in which they are found.
摘要
自组装和自组织原理是分子与细胞生物学的主要原则。在这些原则的支配下，真核细胞核由众多亚结构域和区室组成，统称为核体。新出现的证据表明，各种核体内部以及它们之间与基因组位点的关联是动态的，并且会随着细胞信号而变化。本综述将讨论我们在理解核体成分如何聚集在一起、它们形成时会发生什么以及这些亚细胞结构可能为其所在的组织或生物体带来什么益处方面的最新进展。
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