西贝素 A-D，来自黄槐决明的 BACE1 抑制剂。
Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena.
机构信息
Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
出版信息
Phytochemistry. 2010 Dec;71(17-18):2168-73. doi: 10.1016/j.phytochem.2010.09.008. Epub 2010 Oct 15.
Abstract
Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.
摘要
生物测定导向的从蓝桉果实提取物中进行分段分离，导致了分离出了 sebestenoids A-D（1-4）。根据广泛的 NMR 实验和质谱测量，确定了它们的结构。化合物 1-4 对天冬氨酸蛋白酶 BACE1 表现出中等抑制作用。
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