来自小花风轮菜的基质金属蛋白酶-2抑制剂。
Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.
作者信息
Murata Toshihiro, Sasaki Kenroh, Sato Kumiko, Yoshizaki Fumihiko, Yamada Haruna, Mutoh Hiromichi, Umehara Kaoru, Miyase Toshio, Warashina Tsutomu, Aoshima Hiroaki, Tabata Homare, Matsubara Kouichi
机构信息
Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
出版信息
J Nat Prod. 2009 Aug;72(8):1379-84. doi: 10.1021/np800781t.
From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).
从小花风轮菜的地上部分分离得到了9个新的苯丙素类化合物，即风轮菜酸A - I（2 - 10），同时还得到了一个已知的苯丙素类化合物迷迭香酸（1）。通过光谱分析确定了这些新化合物的结构。风轮菜酸C（4）显示出MMP - 2抑制活性（IC(50)为3.26 microM）。
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