Chambon Marion, Ho Raimana, Baghdikian Beatrice, Herbette Gaëtan, Bun-Llopet Sok-Siya, Garayev Elnur, Raharivelomanana Phila
UMR 214 Ecosystèmes Insulaires Océaniens, Université de Polynésie Française, IFREMER, ILM, IRD, BP 6570, Tahiti, F-98702 Faaa, French Polynesia.
Aix Marseille Univ, CNRS 7263, IRD 237, Avignon Université, IMBE, 27 Blvd Jean Moulin, Service of Pharmacognosy, Faculty of Pharmacy, 13385 Marseille, France.
Antioxidants (Basel). 2023 Oct 16;12(10):1870. doi: 10.3390/antiox12101870.
Oxidative stress contributes to impairment of skin health, the wound healing process, and pathologies such as psoriasis or skin cancer. Five Polynesian medicinal plants, among the most traditionally used for skin care (pimples, wounds, burns, dermatoses) are studied herein for their antioxidant properties: , , , , and . Plant extracts were submitted to in vitro bioassays related to antioxidant properties and their bioactive constituents were identified by a metabolomic analytical approach. High performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) analysis was performed leading to the characterization of 61 metabolites. Compounds annotated for and extracts were reported for the first time. Antioxidant properties were evaluated by total phenolic content (TPC), free radical scavenging DPPH (1,1-diphenyl-2-picryl-hydrazyl), and Ferric Reducing Antioxidant Power activity (FRAP) assays. extract was the most active one and showed antioxidant intracellular activity on keratinocytes by Anti Oxydant Power 1 assay. Online HPLC-DPPH allowed the identification of phenolic bioactive compounds such as quercetin--rhamnoside, rosmarinic acid, chlorogenic acid, procyanidins, epicatechin, 5--caffeoylshikimic acid, and curcumin as being responsible for the scavenging properties of these plant extracts. These results highlight the potential of aerial roots as a source of antioxidants for skin care applications.
氧化应激会导致皮肤健康受损、伤口愈合过程受阻以及引发诸如牛皮癣或皮肤癌等病症。本文研究了五种最常用于皮肤护理（治疗粉刺、伤口、烧伤、皮肤病）的波利尼西亚药用植物的抗氧化特性：[植物名称1]、[植物名称2]、[植物名称3]、[植物名称4]和[植物名称5]。将植物提取物进行与抗氧化特性相关的体外生物测定，并通过代谢组学分析方法鉴定其生物活性成分。采用高效液相色谱串联质谱（HPLC-MS/MS）分析，鉴定出61种代谢物。首次报道了[植物名称1]和[植物名称2]提取物中注释的化合物。通过总酚含量（TPC）、自由基清除DPPH（1,1-二苯基-2-苦基肼）和铁还原抗氧化能力（FRAP）测定来评估抗氧化特性。[植物名称3]提取物活性最强，并通过抗氧化能力1测定法对角质形成细胞显示出细胞内抗氧化活性。在线HPLC-DPPH分析鉴定出酚类生物活性化合物，如槲皮素-鼠李糖苷、迷迭香酸、绿原酸、原花青素、表儿茶素、5-咖啡酰奎尼酸和姜黄素，这些化合物是这些植物提取物具有清除自由基特性的原因。这些结果突出了[植物名称3]气生根作为皮肤护理应用抗氧化剂来源的潜力。
