Department of Cardiology and Respiratory Medicine, Hvidovre Hospital, Copenhagen, Denmark.
Respir Med. 2011 Mar;105(3):410-7. doi: 10.1016/j.rmed.2010.09.019. Epub 2010 Oct 16.
COPD is a leading cause of death worldwide; however, prevalence estimates have varied considerably in previous studies. This study aimed to determine the prevalence and severity of COPD in Copenhagen using data from the 4th examination of The Copenhagen City Heart Study, to investigate the relationship between tobacco consumption and COPD, and to characterize the subjects with COPD with regard to BMI, dyspnoea, treatment with respiratory medication and co-morbidities.
6236 people participated. All non-asthmatic participants aged 35 years or older with adequate lung function data were included for the final prevalence analyses (n = 5,299). COPD staging was done according to the GOLD criteria.
The overall prevalence of COPD was 17.4%. The prevalence increased with age and was higher among males. 6.2% had mild COPD, 9.2% had moderate COPD, and 2.0% had severe or very severe COPD. Tobacco consumption was closely linked to both prevalence and disease severity. Subjects with COPD had lower mean Body Mass Index (BMI) and more frequently a BMI < 21 kg/m(2). Dyspnoea was correlated to lung function but a substantial number of participants with severe COPD experienced no dyspnoea. Only a minority of subjects with COPD received pulmonary medication. COPD was associated with cardiovascular disease and cancer.
The prevalence of COPD in Denmark is among the highest in the world. It is closely correlated to smoking and age. It is accompanied by substantial co-morbidity and it is grossly under treated.
COPD 是全球主要的死亡原因；然而，既往研究中 COPD 的流行率估计差异较大。本研究旨在通过哥本哈根城市心脏研究第四次检查的数据，确定哥本哈根 COPD 的流行率和严重程度，探讨吸烟与 COPD 的关系，并对 COPD 患者的 BMI、呼吸困难、呼吸药物治疗和合并症进行特征描述。
6236 人参与。所有年龄在 35 岁或以上、肺功能数据充分的非哮喘参与者都被纳入最终的流行率分析（n = 5299）。COPD 分期根据 GOLD 标准进行。
COPD 的总体流行率为 17.4%。流行率随年龄增长而增加，男性更高。6.2%为轻度 COPD，9.2%为中度 COPD，2.0%为重度或极重度 COPD。吸烟与流行率和疾病严重程度密切相关。COPD 患者的平均体重指数（BMI）较低，BMI<21 kg/m2 的比例较高。呼吸困难与肺功能相关，但相当一部分严重 COPD 患者没有呼吸困难。只有少数 COPD 患者接受了肺部药物治疗。COPD 与心血管疾病和癌症相关。
丹麦 COPD 的流行率位居世界前列。它与吸烟和年龄密切相关。它伴随着大量的合并症，且严重程度被大大低估。
