Division of Respiratory and Cardiovascular Medicine, Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Respirology. 2010 Nov;15(8):1252-8. doi: 10.1111/j.1440-1843.2010.01854.x.
COPD is one of the leading causes of morbidity and mortality worldwide, and its prevalence continues to increase. Although spirometry is indispensable for the diagnosis of COPD, other simple and reliable tools are necessary for screening of COPD because spirometry is not widely available. This study investigated the usefulness of a combination of an electronic FEV₁/FEV₆ meter (PiKo-6) with a COPD questionnaire as a screening method in patients with cardiovascular diseases.
The PiKo-6 and the COPD questionnaire of the International Primary Care Airways Group were used to screen patients attending a cardiovascular outpatient clinic. Patients with FEV₁/FEV₆ < 70% were defined as having airflow limitation. Patients diagnosed with airflow limitation underwent spirometry. Using data from the PiKo-6 and the COPD questionnaire, patients were assigned to a COPD group or a non-COPD group. The relationship between PiKo-6 measurements and spirometry was also evaluated.
Among 753 patients, 82 (10.9%) showed airflow limitation when assessed with the PiKo-6. Of these patients, 79 (10.5%) were assigned to the COPD group. FEV₁, FEV₆ and FEV₁/FEV₆, as measured with the PiKo-6, correlated significantly with FEV₁, FVC and FEV₁/FVC, respectively, as measured by spirometry (r = 0.865, 0.751 and 0.57). Among the cardiovascular comorbidities, heart failure and ischaemic heart disease showed slightly stronger associations with airflow limitation (13.8% and 12.5%, respectively).
Combination of the PiKo-6 with a COPD questionnaire may be a useful and feasible method of identifying undiagnosed COPD patients attending a cardiovascular outpatient clinic.
COPD 是全球发病率和死亡率的主要原因之一，其患病率仍在继续上升。虽然肺活量计对于 COPD 的诊断是不可或缺的，但对于 COPD 的筛查还需要其他简单可靠的工具，因为肺活量计并不广泛可用。本研究旨在探讨电子 FEV₁/FEV₆ 计（PiKo-6）与 COPD 问卷相结合作为心血管疾病患者筛查方法的有用性。
使用 PiKo-6 和国际初级保健气道组的 COPD 问卷对心血管门诊就诊的患者进行筛查。FEV₁/FEV₆<70%的患者定义为气流受限。诊断为气流受限的患者进行肺活量测定。使用 PiKo-6 和 COPD 问卷的数据，将患者分为 COPD 组和非 COPD 组。还评估了 PiKo-6 测量值与肺活量计之间的关系。
在 753 名患者中，82 名（10.9%）经 PiKo-6 评估存在气流受限。这些患者中有 79 名（10.5%）被分配到 COPD 组。PiKo-6 测量的 FEV₁、FEV₆ 和 FEV₁/FEV₆ 与肺活量计测量的 FEV₁、FVC 和 FEV₁/FVC 分别呈显著相关（r=0.865、0.751 和 0.57）。在心血管合并症中，心力衰竭和缺血性心脏病与气流受限的相关性稍强（分别为 13.8%和 12.5%）。
PiKo-6 与 COPD 问卷相结合可能是一种识别心血管门诊就诊的未诊断 COPD 患者的有用且可行的方法。
