Bispebjerg Hospital, Copenhagen, Denmark.
COPD. 2010 Feb;7(1):5-10. doi: 10.3109/15412550903499506.
Although there are a number of studies on the coexistence of heart disease and COPD among patients acutely admitted to hospital, this relationship has not been accurately described in the general population. Especially data on the prevalence of both reduced lung function and impaired left ventricular ejection fraction (LVEF) are sparse. We used data from the 4th examination of The Copenhagen City Heart Study, which comprises 5,890 individuals with data on pulmonary and cardiac symptoms, risk factors for cardiovascular diseases, pulmonary function tests, ECG and relevant medical history. Among the participants a randomly selected subgroup of 3,469 individuals underwent both spirometry and echocardiography. The participants were classified according to COPD stage using the international GOLD staging according to FEV(1) in % of predicted. The prevalence of COPD was 5.7% for mild COPD (GOLD stage 1), 9.4% for moderate COPD (GOLD stage 2) and 2.5% for severe and very severe COPD (GOLD stages 3+4). Individuals with COPD were older and had a higher prevalence of cardiovascular risk factors and a higher prevalence of cardiovascular diseases. Among the echocardiographical findings, only the presence of left ventricular hyperthrophy was significantly more frequent among individuals with COPD (17.7%) than among participants without COPD (12.1%.), yet this relationship was no longer significant after statistical adjustment for age and gender. In the general population, subjects with COPD have a higher prevalence of cardiovascular diseases and an unfavourable cardiovascular risk profile compared with individuals without COPD, but this was mainly related to higher age among the participants with COPD.
尽管有许多研究关注急性住院患者中心脏病和 COPD 的共存，但在普通人群中，这种关系尚未得到准确描述。特别是关于肺功能降低和左心室射血分数（LVEF）受损的患病率数据很少。我们使用了来自哥本哈根城市心脏研究第 4 次检查的数据，该研究包括 5890 名个体，他们的数据包括肺部和心脏症状、心血管疾病的危险因素、肺功能测试、心电图和相关病史。在参与者中，随机选择了 3469 名个体进行了肺活量测定和超声心动图检查。根据 FEV(1)占预计值的百分比，根据国际 GOLD 分期，将参与者分为 COPD 阶段。轻度 COPD（GOLD 阶段 1）的 COPD 患病率为 5.7%，中度 COPD（GOLD 阶段 2）为 9.4%，严重和非常严重 COPD（GOLD 阶段 3+4）为 2.5%。患有 COPD 的个体年龄较大，且具有更高的心血管危险因素和心血管疾病患病率。在超声心动图发现中，只有左心室肥厚的存在在 COPD 患者（17.7%）中明显比无 COPD 患者（12.1%）更为常见，但在统计学上调整年龄和性别后，这种关系不再显著。在普通人群中，与无 COPD 的个体相比，患有 COPD 的个体具有更高的心血管疾病患病率和不利的心血管风险特征，但这主要与 COPD 患者的年龄较高有关。
