Peterson Todd E, Shokouhi Sepideh, Furenlid Lars R, Wilson Donald W
Institute of Imaging Science and the Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232 USA (telephone: 615-322-2648,
IEEE Trans Nucl Sci. 2009 Jun 16;56(3):646-652. doi: 10.1109/TNS.2009.2012514.
Silicon double-sided strip detectors offer outstanding instrinsic spatial resolution with reasonable detection efficiency for iodine-125 emissions. This spatial resolution allows for multiple-pinhole imaging at low magnification, minimizing the problem of multiplexing. We have conducted imaging studies using a prototype system that utilizes a detector of 300-micrometer thickness and 50-micrometer strip pitch together with a 23-pinhole collimator. These studies include an investigation of the synthetic-collimator imaging approach, which combines multiple-pinhole projections acquired at multiple magnifications to obtain tomographic reconstructions from limited-angle data using the ML-EM algorithm. Sub-millimeter spatial resolution was obtained, demonstrating the basic validity of this approach.
硅双面条带探测器具有出色的固有空间分辨率，对碘-125发射具有合理的探测效率。这种空间分辨率允许在低放大倍数下进行多针孔成像，从而将复用问题降至最低。我们使用了一个原型系统进行成像研究，该系统采用了厚度为300微米、条带间距为50微米的探测器以及一个23针孔准直器。这些研究包括对合成准直器成像方法的研究，该方法将在多个放大倍数下获取的多针孔投影结合起来，使用ML-EM算法从有限角度数据中获得断层重建。获得了亚毫米级的空间分辨率，证明了该方法的基本有效性。
