瑞雷蛋白信号通路、海马神经发生以及阿司匹林摄入与干细胞移植在衰老和阿尔茨海默病中的疗效
Reelin Signaling, Hippocampal Neurogenesis, and Efficacy of Aspirin Intake & Stem Cell Transplantation in Aging and Alzheimer's disease.
作者信息
Shetty Ashok K
机构信息
Department of Surgery (Neurosurgery), Duke University Medical Center, Durham NC 27710 Medical Research Service, Durham Veterans Affairs Medical Center, Durham NC 27705.
出版信息
Aging Dis. 2010 Aug 30;1(2):2-11.
Comprehending the mechanisms underlying the pathophysiology of aging and Alzheimer's disease has immense value for developing strategies that promote successful aging and prevent or cure Alzheimer's disease. The first issue of the new journal, "Aging & Disease" comprises articles that discuss the current knowledge pertaining to changes in reelin signaling in normal & pathological forms of aging, memory and neurogenesis in Aging & Alzheimer's disease, the efficacy of a non-steroidal anti-inflammatory drug aspirin in combination with docosahexaenoic acid for reducing the risk for Alzheimer's disease, and the usefulness of stem cell transplantation for improving memory in aging and Alzheimer's disease. The highlights and the importance of the above issues to Aging and Alzheimer's disease are discussed in this commentary.
了解衰老和阿尔茨海默病病理生理学背后的机制对于制定促进成功衰老以及预防或治愈阿尔茨海默病的策略具有巨大价值。新期刊《衰老与疾病》的第一期包含了一些文章，这些文章讨论了与正常和病理形式衰老过程中Reelin信号变化、衰老和阿尔茨海默病中的记忆与神经发生、非甾体抗炎药阿司匹林与二十二碳六烯酸联合使用降低阿尔茨海默病风险的疗效以及干细胞移植对改善衰老和阿尔茨海默病患者记忆的作用相关的现有知识。本评论讨论了上述问题对衰老和阿尔茨海默病的重要性及亮点。
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