Kinoshita T, Kato J
Department of Obstetrics and Gynecology, Yamanashi Medical College, Japan.
Horm Res. 1990;33 Suppl 2:18-20. doi: 10.1159/000181560.
Fasting insulin concentration and the insulin response to an oral glucose tolerance test were measured in 15 women with polycystic ovary syndrome (PCOS) and 6 weight-matched normal women. The fasting insulin concentrations were not increased in PCOS in comparison to normal women. Insulin response to an oral glucose test was significantly decreased (p less than 0.05) in PCOS at 30 min, although 63% of these women had mild impairment of glucose tolerance. The glucose response did not differ between the obese PCOS patients and those with nonobesity. No correlations were demonstrated between the fasting serum insulin concentrations and insulin response at 30 min, and both androgens and the luteinizing hormone. These findings suggest that (1) hyperinsulinemia is not a feature of PCOS in Japan; (2) only obese PCOS patients have a tendency of abnormalities in insulin secretion; (3) it is evident that PCOS represents an inadequately characterized disorder of insulin action and a novel paradigm in which to investigate the relationship between reproductive functions and carbohydrate metabolism.
对15名多囊卵巢综合征（PCOS）女性和6名体重匹配的正常女性测量了空腹胰岛素浓度以及口服葡萄糖耐量试验后的胰岛素反应。与正常女性相比，PCOS患者的空腹胰岛素浓度并未升高。尽管这些女性中有63%存在轻度糖耐量受损，但PCOS患者在口服葡萄糖试验后30分钟时的胰岛素反应显著降低（p<0.05）。肥胖的PCOS患者与非肥胖患者的葡萄糖反应无差异。空腹血清胰岛素浓度与30分钟时的胰岛素反应之间，以及与雄激素和促黄体生成素之间均未显示出相关性。这些发现表明：（1）在日本，高胰岛素血症并非PCOS的特征；（2）只有肥胖的PCOS患者有胰岛素分泌异常的倾向；（3）显然，PCOS代表了一种胰岛素作用特征尚不充分明确的疾病，是研究生殖功能与碳水化合物代谢之间关系的一种新范式。
