Rubenchik B L, Osinkovskaya N D, Mikhailenko V M, Furman M A, Boim T M
Laboratory of Ecology and Carcinogenesis, R.E. Kavetsky Institute for Oncology Problems, Kiev, USSR.
J Environ Pathol Toxicol Oncol. 1990 Nov-Dec;10(6):290-6.
Presented are the literature data as well as the results of our own investigations on the genotoxic and carcinogenic effects of sodium nitrite (SN). The carcinogenicity of SN detected in animal experiments appears to be related to the formation of nitroso compounds from endogenous nitrosable precursors. Sodium nitrite possesses transforming and promoting effects in cell cultures, as well as mutagenic effects in the bacterial systems, where the predominant effect of SN was compared to that of N-nitrosodimethylamine (NDMA). Prolonged pretreatment with SN amplifies the liver DNA damage in rats in case of NDMA endogenous synthesis.
本文介绍了有关亚硝酸钠（SN）遗传毒性和致癌性的文献数据以及我们自己的研究结果。在动物实验中检测到的SN致癌性似乎与内源性可亚硝化前体形成亚硝基化合物有关。亚硝酸钠在细胞培养中具有转化和促进作用，在细菌系统中具有诱变作用，其中将SN与N-亚硝基二甲胺（NDMA）的主要作用进行了比较。在NDMA内源性合成的情况下，用SN进行长时间预处理会加剧大鼠肝脏的DNA损伤。
