Karpilovskaia E D, Gorban' G P, Pliss M B, Zakharenko L N, Gulich M P
Farmakol Toksikol. 1989 Jul-Aug;52(4):64-7.
Amidopyrine administered in combination with sodium nitrite in the long-term experiment produces the toxic damage of the liver and tumors in rats in connection with endogenic synthesis of carcinogenic nitrosodimethylamine. The inclusion into the animal diet of the polyphenolic complex from Plantago major--plantastine as an inhibitor of the carcinogen synthesis reduced the toxic damage of the liver that was indicated by normalization of biochemical parameters and also decreased the tumor yield from 87.5% to 33.3%. The data obtained may be the basis for the combined use of plantastine with nitrosated drugs that would contribute to carcinogenesis prevention.
在长期实验中，氨基比林与亚硝酸钠联合使用会导致大鼠肝脏毒性损伤和肿瘤，这与致癌亚硝基二甲胺的内源性合成有关。将大车前草中的多酚复合物——plantastine作为致癌物合成抑制剂添加到动物饮食中，可减轻肝脏的毒性损伤，这通过生化参数的正常化得以体现，同时肿瘤发生率也从87.5%降至33.3%。所得数据可能为plantastine与亚硝化药物联合使用提供依据，这将有助于预防癌症发生。
