Lambiase Antonietta, Catania Maria Rosaria, Rossano Fabio
Department of Cellular and Molecular Biology and Pathology Luigi Califano, Medical School, Federico II University, Naples, Italy.
New Microbiol. 2010 Jul;33(3):185-94.
Depletion of the periciliary liquid in "Cystic Fibrosis" airway disease results in reduced mucociliary transport, persistent mucus hypersecretion and consequently increased height of the luminal mucus layer, so hypoxic gradients in the mucus plugs are developed. Because of anaerobic lung zones, it is highly probable that anaerobic bacteria not detected by routine bacteriologic culture methods also reside within the mucus. Notwithstanding this evidence, microbiology laboratories working in the cystic fibrosis field do not generally use strict anaerobic bacteriologic cultures to determine the presence of anaerobic bacteria in the Cystic Fibrosis lung. The aim of this review is to focus on the published data regarding the finding of anaerobic bacteria in cystic fibrosis airway disease. Therefore, microbiology, diagnosis, antimicrobial susceptibility and possible impact on clinical management of anaerobic bacteria lung infection in cystic fibrosis are described.
“囊性纤维化”气道疾病中纤毛周围液体的消耗导致黏液纤毛运输减少、黏液持续分泌过多，进而导致管腔黏液层高度增加，因此黏液栓中会形成缺氧梯度。由于存在无氧肺区，很可能常规细菌培养方法未检测到的厌氧菌也存在于黏液中。尽管有这些证据，但在囊性纤维化领域工作的微生物学实验室一般不采用严格的厌氧菌培养来确定囊性纤维化肺部是否存在厌氧菌。本综述的目的是聚焦于已发表的关于在囊性纤维化气道疾病中发现厌氧菌的数据。因此，本文描述了囊性纤维化中厌氧菌肺部感染的微生物学、诊断、抗菌药敏性以及对临床管理可能产生的影响。
