Université de Toulouse, UPS, UMR 152 (Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox), F-31062 Toulouse Cedex 9, France.
J Nat Prod. 2010 Nov 29;73(11):1884-90. doi: 10.1021/np1005357. Epub 2010 Oct 18.
Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC(50) 2.0 and 1.8 μM, respectively) with moderate cytotoxicity on murine macrophages.
从 Piper sanguineispicum 的叶子中分离得到了三种新的咖啡酸酯（1-3）、四种新的木脂素（4-7）以及已知化合物（7'S）-parabenzlactone（8）、二氢胡椒碱（9）和 justiflorinol（10）。通过光谱方法，包括 1D 和 2D NMR、HRCIMS、CD 实验和化学方法确定了它们的结构。评估了化合物 1-10 对无细胞亲脂体形式的 Leishmania amazonensis 的抗利什曼原虫活性。咖啡酸酯 1 和 3 表现出最好的抗利什曼原虫活性（IC50 分别为 2.0 和 1.8 μM），对小鼠巨噬细胞的细胞毒性适中。
