McGill University, Biomedical Engineering, 3775 University Street, Montreal, Quebec, Canada.
Expert Opin Biol Ther. 2010 Dec;10(12):1649-61. doi: 10.1517/14712598.2010.528387. Epub 2010 Oct 18.
Over the past years, extensive research has been directed towards tissue engineering using conventional scaffolds. In-depth studies in this field have led to the realization that in vivo cells interact with the extracellular matrix, composed of nanofibers at sub-micron scale, which not only provides the mechanical support to the cells but also plays a key role in regulation of cellular behavior. This has led to the development of nanofibrous scaffold (NFS) technology which in combination with stem cells is emerging as an important tool in the development of tissue engineering and regenerative medicine.
This review summarizes the three methods of nanofibrous scaffold preparation and provides a state-of-the-art update on the recent advancement in the use of nanoscaffolds in stem cell regeneration therapy.
The review gives the reader an insight on nanoscaffold based therapy methods, such as how these scaffolds can potentially be designed and used in successful development of stem cell based therapies.
NFS technology when coupled with stem cells and exploited in the right way has a strong potential of being used in stem cell based regenerative medicine.
在过去的几年中，大量的研究都集中在使用传统支架的组织工程上。在该领域的深入研究已经使人们认识到，体内细胞与由亚微米尺度的纳米纤维组成的细胞外基质相互作用，纳米纤维不仅为细胞提供机械支撑，而且在调节细胞行为方面也起着关键作用。这导致了纳米纤维支架（NFS）技术的发展，该技术与干细胞结合，正在成为组织工程和再生医学发展的重要工具。
本综述总结了三种纳米纤维支架的制备方法，并提供了纳米支架在干细胞再生治疗中的最新进展的最新情况。
该综述使读者对基于纳米支架的治疗方法有了深入的了解，例如这些支架如何能够在基于干细胞的治疗方法的成功开发中进行潜在的设计和使用。
NFS 技术与干细胞结合并以正确的方式加以利用，具有很强的潜力可用于基于干细胞的再生医学。
