Gencoglan Gulsum, Ceylan Can, Kazandi Ali Can
Department of Dermatology, Medical Faculty of Celal Bayar University, Manisa, Turkey.
Cutan Ocul Toxicol. 2011 Mar;30(1):69-71. doi: 10.3109/15569527.2010.521223. Epub 2010 Oct 18.
A 56-year-old white man with multiple, discrete nonfollicular papules on the neck is presented. Clinical and histopathologic features were compatible with the entity of white fibrous papulosis of the neck (WFPN). Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) and WFPN are further clinicopathologic patterns of intrinsic aging. Clinically, WFPN is characterized by isolated, whitish papules, whereas those of PXE-PDE are yellowish and often coalesce to form "cobblestone" plaques. Our case showed clearly marginated whitish papules. The major histopathologic feature of WFPN is superficial dermal fibrosis with scant elastolysis; in PXE-PDE, there is papillary dermal elastolysis but no sign of fibrosis. No recurrence was performed in the 3 years' follow-up in our case. Surgical treatment may be considered in such cases with well-circumscribed lesions.
本文报告了一名56岁白人男性,其颈部出现多个离散的非毛囊性丘疹。临床和组织病理学特征与颈部白色纤维性丘疹病(WFPN)相符。弹性假黄瘤样乳头真皮弹力纤维溶解症(PXE-PDE)和WFPN是皮肤自然老化的进一步临床病理表现形式。临床上,WFPN的特征为孤立的白色丘疹,而PXE-PDE的丘疹为黄色,常融合形成“鹅卵石”样斑块。我们的病例显示为边界清晰的白色丘疹。WFPN的主要组织病理学特征是真皮浅层纤维化伴少量弹力纤维溶解;在PXE-PDE中,存在乳头真皮弹力纤维溶解但无纤维化迹象。我们的病例在3年随访中未复发。对于病变边界清晰的此类病例,可考虑手术治疗。