Rongioletti F, Rebora A
Department of Dermatology, University of Genoa, Italy.
Dermatology. 1995;191(1):19-24. doi: 10.1159/000246478.
Cutaneous aging is due to intrinsic and extrinsic factors. While the pathologic hallmark of extrinsic aging (photoaging) is solar elastosis, intrinsic aging lacks any specific feature. Only a progressive thinning and loss of the dermal elastic network occasionally associated with focal thickening of the collagen bundles may be observed. In contrast to the different clinical patterns of solar elastosis, only one distinctive disorder has been related so far to intrinsic aging: the temporary wrinkles.
Pseudoxanthoma-elasticum-like papillary dermal elastolysis (PDE) and white fibrous papulosis of the neck (WFP) are further clincopathologic patterns of intrinsic aging.
Review of the literature and clinical and histologic studies of patients of our files.
PDE and WFP share some peculiar clinical and histologic features, namely their occurrence in late adulthood and thinning or loss of the elastic fibers, mainly in the papillary dermis. Moreover, elastolysis in PDE and focal fibrosis in WFP, along with the abnormal elastic fibers, immature elastogenesis and activation of fibroblasts observed in PDE, are quite similar to the changes described in intrinsic aging.
PDE and WFP along with temporary wrinkles and some cases of noninflammatory middermal elastolysis could be classified as 'age-related fibroelastolytic syndromes'.
皮肤老化是由内在和外在因素引起的。外在老化（光老化）的病理标志是日光性弹力组织变性，而内在老化缺乏任何特定特征。仅可观察到真皮弹性网络逐渐变薄和丧失，偶尔伴有胶原束局灶性增厚。与日光性弹力组织变性的不同临床模式相反，迄今为止，仅有一种独特的病症与内在老化有关：暂时性皱纹。
弹性假黄瘤样乳头真皮弹力纤维松解症（PDE）和颈部白色纤维丘疹病（WFP）是内在老化的进一步临床病理模式。
回顾文献以及对我们档案中患者的临床和组织学研究。
PDE和WFP具有一些独特的临床和组织学特征，即它们发生于成年后期，且弹性纤维变薄或丧失，主要发生在乳头真皮。此外，PDE中的弹力纤维松解和WFP中的局灶性纤维化，以及PDE中观察到的异常弹性纤维、未成熟的弹性生成和成纤维细胞活化，与内在老化中描述的变化非常相似。
PDE和WFP连同暂时性皱纹以及一些非炎性中层弹力纤维松解症病例可归类为“年龄相关性纤维弹力纤维松解综合征”。
