El Jalkh Jason, Obeid Pia Maria, Guermazi Dorra, Soubra Aya, Saliba Elie
Department of Dermatology, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 13-5053, Lebanon.
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Dermatopathology (Basel). 2025 May 14;12(2):15. doi: 10.3390/dermatopathology12020015.
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and topical calcineurin inhibitor. Histopathologic examination showed a regular epidermis with increased melanophages in the papillary dermis, without vacuolar degeneration of the basement membrane. Verhoeff Van Gieson stain highlighted a band-like zone of attenuated elastic fibers in the papillary dermis, while Von Kossa stain was negative for calcified fibers. PAS staining was negative for fungal organisms and Alcian blue showed no increase in dermal mucin.
一名64岁患者因过去两年间颈部外侧对称分布的有症状的肤色丘疹前来就诊，这些丘疹在使用多种外用糖皮质激素、抗真菌乳膏和外用钙调神经磷酸酶抑制剂后均未见改善。组织病理学检查显示表皮正常，乳头真皮层中巨噬细胞增多，基底膜无空泡变性。Verhoeff Van Gieson染色突出显示乳头真皮层中弹性纤维呈带状变薄区域，而Von Kossa染色显示钙化纤维为阴性。PAS染色显示真菌阴性，阿尔辛蓝染色显示真皮粘蛋白无增加。
