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棘白菌素类药物在毛霉目中的活性：种属和外源性铁的影响。

Activity of deferasirox in Mucorales: influences of species and exogenous iron.

机构信息

Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Antimicrob Agents Chemother. 2011 Jan;55(1):411-3. doi: 10.1128/AAC.00792-10. Epub 2010 Oct 18.

DOI:10.1128/AAC.00792-10
PMID:20956598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3019624/
Abstract

Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.

摘要

粘帚霉目成员间的地拉罗司药敏性差异尚不清楚。本研究显示，与根毛霉属（6 株）相比，卷枝毛霉（4 株）和毛霉（5 株）的地拉罗司 MIC 和最低杀菌浓度更高。低 MIC 的粘帚霉目分离株对外源铁进一步降低了地拉罗司的敏感性。活细胞染色显示，易感株亚顶区结构受到破坏。

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本文引用的文献

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The iron chelator deferasirox protects mice from mucormycosis through iron starvation.铁螯合剂地拉罗司通过铁饥饿保护小鼠免受毛霉菌病侵害。
J Clin Invest. 2007 Sep;117(9):2649-57. doi: 10.1172/JCI32338.
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Invasive zygomycosis: update on pathogenesis, clinical manifestations, and management.侵袭性接合菌病：发病机制、临床表现及治疗的最新进展
Infect Dis Clin North Am. 2006 Sep;20(3):581-607, vi. doi: 10.1016/j.idc.2006.06.003.
3
Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload.与去铁胺相比，每日一次口服铁螯合剂地拉罗司（Exjade，ICL670）治疗输血性铁过载地中海贫血患者的随机II期试验。
Haematologica. 2006 Jul;91(7):873-80.
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Epidemiology and outcome of zygomycosis: a review of 929 reported cases.毛霉菌病的流行病学与转归：929例报告病例的综述
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5
Testing conditions for determination of minimum fungicidal concentrations of new and established antifungal agents for Aspergillus spp.: NCCLS collaborative study.测定新型及已确立的抗真菌药物对曲霉属最低杀菌浓度的试验条件：美国国家临床实验室标准委员会协作研究
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The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro.抗真菌棘白菌素类药物醋酸卡泊芬净在体外可杀死烟曲霉的生长细胞。
Antimicrob Agents Chemother. 2002 Sep;46(9):3001-12. doi: 10.1128/AAC.46.9.3001-3012.2002.
7
In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi.伏立康唑、伊曲康唑和两性霉素B对机会性念珠菌和暗色真菌的体外杀真菌活性。
J Clin Microbiol. 2001 Mar;39(3):954-8. doi: 10.1128/JCM.39.3.954-958.2001.
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Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies.去铁胺治疗期间的毛霉病是一种铁载体介导的感染。体外和体内动物研究。
J Clin Invest. 1993 May;91(5):1979-86. doi: 10.1172/JCI116419.
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The effect of deferoxamine on different zygomycetes.去铁胺对不同接合菌纲真菌的作用。
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Iron uptake from ferrioxamine and from ferrirhizoferrin by germinating spores of Rhizopus microsporus.微小根霉萌发孢子对铁载体和根铁载体中铁的吸收。
Biochem Pharmacol. 1994 May 18;47(10):1843-50. doi: 10.1016/0006-2952(94)90314-x.