Chen Kuo, Xiao Zhan-sen, Hou Shu-qin, Zhao Run-tian, Liu Yue-feng, Dou Hui-dong, Li Guang-ping, Tao Xiao-ming, Li Feng, Zhou Wen-yu, Qiu Chang-chun
National Laboratory of Medical Molecular Biology, Institution of Basic Medical Science, Clinic Academy of Medical Science & Peking Union Medical College, Beijing 100005, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Oct 18;42(5):498-502.
To investigate the association between the NINJ2 gene rs11833579 polymorphism and stroke in Han Chinese population.
This study was a population-based cross-sectional case-control study. Polymerase chain reaction-restriction fragment length polymorphism (RFLP) and sequencing were used for the detection of NINJ2 genotypes in 790 patients with stroke (679 ischemic stroke) which were Han Chinese population from Fangshan First Hospital and 811 controls which were healthy Han Chinese population without family history of stroke in Fangshan district rural area.
In rs11833579 locus of the NINJ2 gene, the frequencies of GG genotype and allele G were higher in ischemic stroke patients than that in controls (P<0.001). The frequency of allele G of the NINJ2 gene was higher in cerebral hemorrhage patients than that in controls (P=0.005). Genotype had little effect on the glucose, total cholesterol and triglyceride.
There is significant association between rs11833579 site polymorphism of the NINJ2 gene and risk for stroke in Han Chinese population from Fangshan district.
探讨NINJ2基因rs11833579多态性与汉族人群中风的相关性。
本研究为基于人群的横断面病例对照研究。采用聚合酶链反应-限制性片段长度多态性（RFLP）和测序技术，对来自房山区第一医院的790例汉族中风患者（679例缺血性中风）及房山区农村地区811例无中风家族史的汉族健康对照者的NINJ2基因进行基因型检测。
在NINJ2基因的rs11833579位点，缺血性中风患者的GG基因型和等位基因G的频率高于对照组（P<0.001）。脑出血患者中NINJ2基因的等位基因G频率高于对照组（P=0.005）。基因型对血糖、总胆固醇和甘油三酯影响较小。
房山区汉族人群中，NINJ2基因rs11833579位点多态性与中风风险存在显著相关性。
