Ozdemir Osman, Oguz Deniz, Atmaca Emel, Sanli Cihat, Yildirim Ayse, Olgunturk Rana
Department of Pediatric Cardiology, Kecioren Training and Research Hospital, Ankara, Turkey.
Pediatr Cardiol. 2011 Jan;32(1):55-8. doi: 10.1007/s00246-010-9814-6. Epub 2010 Oct 19.
The existence of cardiac damage in active rheumatic carditis patients is unknown, especially in those without pericarditis. The aim of this study was to determine cardiac myocyte damage using cardiac troponin T (cTnT) measurements in active rheumatic carditis. The levels of creatine kinase MB isoenzyme (CK-MB), cTnT, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), cardiothoracic ratio (CTR), and fractional shortening (FS) were compared using Mann-Whitney U test between 28 patients with active rheumatic carditis and 32 controls (healthy children). Association of cTnT levels with ESR, CRP, and CTR was evaluated with Spearman correlation analysis. ESR, CRP, cTnT levels, and CTR were statistically higher in the patients than in the controls. There were no differences between the groups for CK-MB levels and FS. No relationships were found between cTnT levels and ESR, CRP, and CTR in the patient group. The results of the study suggest that when cTnT levels are within non-pathological range, there is no serious cardiac damage; however, statistically significant increases in cTnT levels may indicate minor damages in patients with active carditis due to acute rheumatic fever.
活动性风湿性心肌炎患者是否存在心脏损伤尚不清楚，尤其是那些没有心包炎的患者。本研究的目的是通过检测活动性风湿性心肌炎患者的心肌肌钙蛋白T（cTnT）来确定心肌细胞损伤情况。使用曼-惠特尼U检验比较了28例活动性风湿性心肌炎患者和32名对照者（健康儿童）的肌酸激酶MB同工酶（CK-MB）、cTnT、红细胞沉降率（ESR）、C反应蛋白（CRP）、心胸比率（CTR）和缩短分数（FS）水平。采用Spearman相关分析评估cTnT水平与ESR、CRP和CTR之间的相关性。患者的ESR、CRP、cTnT水平和CTR在统计学上高于对照组。两组之间的CK-MB水平和FS没有差异。在患者组中，未发现cTnT水平与ESR、CRP和CTR之间存在相关性。研究结果表明，当cTnT水平处于非病理范围内时，不存在严重的心脏损伤；然而，cTnT水平在统计学上的显著升高可能表明急性风湿热所致活动性心肌炎患者存在轻微损伤。
