Haffejee I E, Coutts P, Moosa A
J Trop Med Hyg. 1984 Oct;87(5):215-8.
Total serum creatine kinase (CK) and the MB fraction of CK (CK-MB) activities were measured in 36 patients with active rheumatic carditis and on 33 controls. There were no significant differences in either the total CK or the CK-MB between the two groups. However, eight out of the 36 carditis patients had received intramuscular injections (IMI) prior to the assay: this sub-group showed a significant elevation of the total CK but not the CK-MB. Ten carditis patients (without prior IMI) had repeat assays done after their rheumatic activity had subsided: the mean total CK, but not the CK-MB, fell to levels below control values although these were not statistically significant. The results show that CK-MB is not of value in assessing activity in rheumatic carditis. Further, in assessing the significance of elevated total CK in any clinical situation, the influence of IMI and of bed rest should be taken into account.
对36例活动性风湿性心脏炎患者和33例对照者测定了血清总肌酸激酶（CK）及CK的MB同工酶（CK-MB）活性。两组患者的总CK或CK-MB均无显著差异。然而，36例心脏炎患者中有8例在检测前接受过肌肉注射：该亚组患者的总CK显著升高，但CK-MB未升高。10例心脏炎患者（未接受过肌肉注射）在风湿活动消退后进行了重复检测：尽管差异无统计学意义，但总CK的平均值降至低于对照值的水平，而CK-MB未下降。结果表明，CK-MB对评估风湿性心脏炎的活动情况无价值。此外，在评估任何临床情况下总CK升高的意义时，应考虑肌肉注射和卧床休息的影响。
