The effect of glutathion on the reaction of cis-and trans-diamminedichloroplatinum(II) with DNA.
作者信息
Oliński R
机构信息
Institute of Biochemistry, University of Lódz, Poland.
出版信息
Z Naturforsch C J Biosci. 1990 Nov-Dec;45(11-12):1207-9. doi: 10.1515/znc-1990-11-1220.
PMID:2095789
Abstract
Differential pulse polarography study was used to investigate the influence of glutathion on cis- and trans-DDP induced alterations of DNA structure. Though the applied concentration of glutathion has no effect on the reaction on DNA with cis-DDP, it greatly modifies the reaction with trans isomer. This may be an important reason for the ineffectiveness of the trans-DDP as an antitumor drug.
摘要
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