Olesen J, Hougård K, Hertz M
Stroke. 1978 Jul-Aug;9(4):344-9. doi: 10.1161/01.str.9.4.344.
Using the "double indicator" technique the ability of 3H-isoproterenol and 14C-propranolol to cross the blood-brain barrier was studied in man. In 3 subjects extraction of isoproterenol was 3.8% in a single passage and the PS product was 2.0 ml/100g/min. In 4 patients extraction of propranolol was 63% and PS was 46.7 ml/100/min. Regional cerebral blood flow (rCBF) was studied in man with the 133Xe-intraarterial injection method. Intracarotid isoproterenol (3 migrogram/min., 6 patients) caused a significant reduction in rCBF, but after correction for a concomitant decrease in arterial PCO2 the alteration was no longer significant (59.8 -51.7/57.4 ml/100g/min.). Intracarotid propranolol (0.15 mg/kg, 11 patients) caused no significant change in rCBF, but after correction for arterial PCO2 change the lateration although on 4% was just significant, p less than 0.05. (56.3 -55.8/54.1 ml/100g/min). After propranolol the rCBF changes caused by alterations in the arterial PCO2 were normal and the focal flow increase during hand work could not be changed by simultaneous intracarotid propranolol.
采用“双指标”技术，在人体中研究了3H-异丙肾上腺素和14C-普萘洛尔穿越血脑屏障的能力。在3名受试者中，异丙肾上腺素单次通过时的摄取率为3.8%，PS乘积为2.0 ml/100g/min。在4名患者中，普萘洛尔的摄取率为63%，PS为46.7 ml/100/min。采用133Xe动脉内注射法在人体中研究了局部脑血流量（rCBF）。颈内注射异丙肾上腺素（3微克/分钟，6名患者）导致rCBF显著降低，但在纠正伴随的动脉PCO2降低后，这种改变不再显著（59.8 -51.7/57.4 ml/100g/min）。颈内注射普萘洛尔（0.15 mg/kg，11名患者）未引起rCBF显著变化，但在纠正动脉PCO2变化后，尽管变化仅为4%，但仍具有统计学意义，p<0.05（56.3 -55.8/54.1 ml/100g/min）。普萘洛尔给药后，由动脉PCO2改变引起的rCBF变化正常，同时颈内注射普萘洛尔不会改变手部运动时的局部血流增加。
