Olesen J
Cephalalgia. 1986;6 Suppl 5:41-6. doi: 10.1177/03331024860060S505.
Noradrenaline, adrenaline, and isoprenaline were infused intracarotidly and the regional cerebral blood flow measured with the intracarotid injection-stationary detector method in patients undergoing carotid angiography. No effect was seen, and beta blockade with intracarotid propranolol also had no effect. The adrenergic effects on cerebral blood vessels are probably neurogenic, and circulating adrenergic agonists and antagonists are unlikely to play a role. Pertubations of adrenergic substances in blood are therefore unlikely to be important in migraine pathophysiology.
去甲肾上腺素、肾上腺素和异丙肾上腺素经颈动脉内注入，并采用颈动脉内注射-固定探测器法对接受颈动脉血管造影的患者测量局部脑血流量。未观察到任何影响，经颈动脉内注射普萘洛尔进行β受体阻滞也无效果。肾上腺素能对脑血管的作用可能是神经源性的，循环中的肾上腺素能激动剂和拮抗剂不太可能起作用。因此，血液中肾上腺素能物质的扰动在偏头痛病理生理学中不太可能起重要作用。
