肿瘤内异质性的起源和意义。
The origins and implications of intratumor heterogeneity.
机构信息
Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Cancer Prev Res (Phila). 2010 Nov;3(11):1361-4. doi: 10.1158/1940-6207.CAPR-10-0234. Epub 2010 Oct 19.
Abstract
Human tumors often display startling intratumor heterogeneity in various features including histology, gene expression, genotype, and metastatic and proliferative potential. This phenotypic and genetic heterogeneity plays an important role in neoplasia, cancer progression, and therapeutic resistance. In this issue of the journal (beginning on page 1388), Merlo et al. report their use of molecular data from 239 patients with Barrett's esophagus to evaluate the propensity of major diversity indices for predicting progression to esophageal adenocarcinoma. This work helps elucidate the implications of molecular heterogeneity for the evolution of neoplasia.
摘要
人类肿瘤在组织学、基因表达、基因型以及转移和增殖潜能等方面经常表现出惊人的肿瘤内异质性。这种表型和遗传异质性在肿瘤发生、癌症进展和治疗抵抗中起着重要作用。在本期杂志上（从第 1388 页开始），Merlo 等人报告了他们使用 239 名 Barrett 食管患者的分子数据来评估主要多样性指数预测食管腺癌进展的倾向。这项工作有助于阐明分子异质性对肿瘤进化的影响。
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