• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

关于糖皮质激素作为兴奋剂的促效作用的证据存在风险。

Evidence on ergogenic action of glucocorticoids as a doping agent risk.

机构信息

Department of Sport Medicine and Functional Explorations, University-Hospital (CHU), Hôpital G. Montpied, Clermont-Ferrand, France.

出版信息

Phys Sportsmed. 2010 Oct;38(3):121-7. doi: 10.3810/psm.2010.10.1817.

DOI:10.3810/psm.2010.10.1817
PMID:20959705
Abstract

Systemic administration of glucocorticoids (GCs) is banned by the World Anti-Doping Agency (WADA) during competition. Few studies have examined the effects of GCs on exercise performance, but increasing evidence has shown that short-term GC intake enhances performance in animals and humans. However, there are many health risks associated with GC use. Based on the available evidence, as presented in this article, I conclude that GCs are doping agents and should remain on the WADA's list of banned products. Because of the complexity of GCs, however, determining the boundaries between their medical use and abuse (eg, in sports) is a constant challenge for the WADA.

摘要

世界反兴奋剂机构(WADA)禁止运动员在比赛期间进行全身糖皮质激素(GCs)治疗。虽然有一些研究探讨了 GCs 对运动表现的影响,但越来越多的证据表明,短期 GCs 摄入可以提高动物和人类的运动表现。然而,GCs 的使用也存在许多健康风险。基于本文中呈现的现有证据,我认为 GCs 是兴奋剂,应该继续被列入 WADA 的禁药名单。然而,由于 GCs 的复杂性,确定其在医学用途和滥用(例如,在运动中)之间的界限,对 WADA 来说是一个持续的挑战。

相似文献

1
Evidence on ergogenic action of glucocorticoids as a doping agent risk.关于糖皮质激素作为兴奋剂的促效作用的证据存在风险。
Phys Sportsmed. 2010 Oct;38(3):121-7. doi: 10.3810/psm.2010.10.1817.
2
Glucocorticoids: a doping agent?糖皮质激素:一种兴奋剂?
Endocrinol Metab Clin North Am. 2010 Mar;39(1):107-26, ix-x. doi: 10.1016/j.ecl.2009.10.001.
3
Glucocorticoid administration in athletes: Performance, metabolism and detection.运动员使用糖皮质激素:表现、代谢与检测
Steroids. 2016 Nov;115:193-202. doi: 10.1016/j.steroids.2016.09.008. Epub 2016 Sep 16.
4
[Medication, athletes and doping regulations].[药物、运动员与反兴奋剂规定]
Ned Tijdschr Geneeskd. 2008 Aug 16;152(33):1844-8.
5
Doping and musculoskeletal system: short-term and long-lasting effects of doping agents.兴奋剂与肌肉骨骼系统:兴奋剂短期和长期的影响。
Fundam Clin Pharmacol. 2011 Oct;25(5):535-63. doi: 10.1111/j.1472-8206.2010.00881.x. Epub 2010 Oct 6.
6
Gene doping.基因兴奋剂。
Int J Sports Med. 2006 Apr;27(4):257-66. doi: 10.1055/s-2006-923986.
7
Harmonization of anti-doping rules in a global context (World Anti-Doping Agency-laboratory accreditation perspective).全球背景下反兴奋剂规则的协调统一(从世界反兴奋剂机构 - 实验室认证角度)
Bioanalysis. 2012 Jul;4(13):1603-11. doi: 10.4155/bio.12.152.
8
Doping droops.兴奋剂使用量下降。
Indian J Physiol Pharmacol. 2007 Apr-Jun;51(2):118-30.
9
Glucocorticoids at the Olympic Games: state-of-the-art review.奥运会上的糖皮质激素:最新综述。
Br J Sports Med. 2016 Oct;50(20):1267. doi: 10.1136/bjsports-2016-096664. Epub 2016 Jul 29.
10
Why glucocorticoids ought to be kept on the World Antidoping Agency's list of banned products.
Br J Sports Med. 2008 Dec;42(12):946-7. doi: 10.1136/bjsm.2008.053397. Epub 2008 Oct 6.

引用本文的文献

1
Safety Implications of Off-Label Medication Use in Athletes: A Narrative Review.运动员超说明书用药的安全性影响:一项叙述性综述
Medicines (Basel). 2024 Nov 15;11(8):20. doi: 10.3390/medicines11080020.
2
Derivatization-Enhanced Analysis of Glucocorticoids for Structural Characterization by Gas Chromatography-Orbitrap High-Resolution Mass Spectrometry.衍生化增强分析糖皮质激素的结构特征气相色谱-轨道阱高分辨率质谱法。
Molecules. 2023 Dec 29;29(1):200. doi: 10.3390/molecules29010200.
3
Glucocorticoids and physical performance: A systematic review with meta-analysis of randomized controlled trials.
糖皮质激素与身体机能:一项对随机对照试验的系统评价及荟萃分析
Front Sports Act Living. 2023 Mar 23;5:1108062. doi: 10.3389/fspor.2023.1108062. eCollection 2023.
4
Urinary excretion profile of prednisolone and prednisone after rectal administration: Significance in antidoping analysis.直肠给予后泼尼松龙和泼尼松的尿排泄谱:在反兴奋剂分析中的意义。
Drug Test Anal. 2022 Nov;14(11-12):2007-2016. doi: 10.1002/dta.3352. Epub 2022 Aug 12.
5
Mechanisms and Clinical Applications of Glucocorticoid Steroids in Muscular Dystrophy.糖皮质激素在肌肉萎缩症中的作用机制及临床应用。
J Neuromuscul Dis. 2021;8(1):39-52. doi: 10.3233/JND-200556.
6
Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice.靶向糖皮质激素-Krüppel 样因子 15-支链氨基酸信号通路的干预措施可改善肌萎缩侧索硬化症小鼠的疾病表型。
EBioMedicine. 2018 May;31:226-242. doi: 10.1016/j.ebiom.2018.04.024. Epub 2018 May 4.
7
Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.糖皮质激素通过特定的代谢程序增强肌肉耐力并改善杜氏肌营养不良症。
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6780-9. doi: 10.1073/pnas.1512968112. Epub 2015 Nov 23.
8
Glucocorticoids improve high-intensity exercise performance in humans.糖皮质激素可提高人体高强度运动表现。
Eur J Appl Physiol. 2014 Feb;114(2):419-24. doi: 10.1007/s00421-013-2784-7. Epub 2013 Dec 11.
9
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.Kruppel 样因子 15 调节骨骼肌脂质通量和运动适应。
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6739-44. doi: 10.1073/pnas.1121060109. Epub 2012 Apr 9.