Katenkamp D
Institut für Pathologie, Klinikum der Friedrich-Schiller-Universität Jena, Ziegelmühlenweg 1, 07743 Jena, Deutschland.
Pathologe. 2011 Feb;32(1):8-13. doi: 10.1007/s00292-010-1391-1.
The classification of soft tissue tumors is based on their resemblance to normal non-neoplastic tissues and provides an indication of how the tumor will behave in the further disease course. The current article presents the principles to be considered when classifying tumors into categories and discusses additional findings to be taken into account in the diagnosis. The importance of considering combinations of findings when classifying a tumor is underscored; individual (in particular immunohistochemical) findings can be misleading. A statement on the grade of malignancy of a soft tissue tumor requires its identification as a known entity, otherwise incorrect prediction of its biological behaviour is possible. The category of "intermediate malignancy" has been added to the categories of "benign" and "malignant", whereby locally aggressive and incidentally metastasizing tumors have been included in this new category. The staging of soft tissue tumors according to the TNM system is explained, emphasizing that one important feature compared with carcinomas is the inclusion of depth localisation and grade of malignancy.
软组织肿瘤的分类基于它们与正常非肿瘤组织的相似性，并为肿瘤在后续病程中的行为提供了一个指示。本文介绍了将肿瘤分类时应考虑的原则，并讨论了诊断中需考虑的其他发现。强调了在对肿瘤进行分类时考虑多种发现组合的重要性；个别（特别是免疫组化）发现可能会产生误导。对软组织肿瘤恶性程度的判断需要将其识别为一个已知实体，否则可能会对其生物学行为做出错误预测。在“良性”和“恶性”类别之外增加了“中间恶性”类别，局部侵袭性和偶发性转移肿瘤被纳入这一新类别。解释了根据TNM系统对软组织肿瘤进行分期的方法，强调与癌相比的一个重要特征是纳入了深度定位和恶性程度。
