Petersen I
Institut für Pathologie, Universitätsklinikum Jena, Ziegelmühlenweg 1, Jena, Germany.
Pathologe. 2013 Sep;34(5):436-48. doi: 10.1007/s00292-013-1784-z.
The new World Health Organization (WHO) classification presents a comprehensive description of soft tissue tumors which was published in book format at the beginning of 2013. Changes have been made relating to the allocation of known entities, e.g. undifferentiated sarcomas are formed into a new group and are not longer assigned to the so-called fibrohistiocytic tumors and new subgroups were incorporated, such as nerve sheath tumors and gastrointestinal stroma tumors which were previously included in the tumor classification of other organ systems. This development is important from the practical point of view as most of relevant soft tissue tumors are now summarized and can be found in a single book. This is also related to the rapid increase in knowledge of the genetics and cell biology of soft tissue tumors. At present there is considerable progress in tumor pathology illustrated by the fact that important new findings have been published after completion of the classification, such as those related to the identification of the recurrent NAB2-STAT6 gene fusion in solitary fibrous tumors and the detection of frequent mutations in the promoter of the hTERT gene in malignant melanoma. In this report some new findings and clinically relevant aspects of soft tissue tumor pathology will be presented.
世界卫生组织（WHO）的新分类对软组织肿瘤进行了全面描述，该分类于2013年初以书籍形式出版。在已知实体的分类方面有一些变化，例如未分化肉瘤被归为一个新组，不再被归入所谓的纤维组织细胞瘤，并且纳入了新的亚组，如神经鞘瘤和胃肠道间质瘤，它们之前被纳入其他器官系统的肿瘤分类中。从实际角度来看，这一进展很重要，因为现在大多数相关软组织肿瘤都被汇总在一本书中。这也与软组织肿瘤遗传学和细胞生物学知识的快速增长有关。目前肿瘤病理学有了显著进展，分类完成后有重要新发现发表就是例证，比如在孤立性纤维瘤中发现复发性NAB2 - STAT6基因融合，以及在恶性黑色素瘤中检测到hTERT基因启动子频繁突变。在本报告中，将介绍软组织肿瘤病理学的一些新发现和临床相关方面。
