Department of Endocrinology and Metabolism Disease, Ege University Medical School, Bornova, 35100 Izmir, Turkey.
Endocrine. 2010 Jun;37(3):449-54. doi: 10.1007/s12020-010-9329-1. Epub 2010 Apr 14.
Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD) and may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of this study was to investigate the association of plasma TAFI antigen level in the development of diabetic foot ulcer in Type 2 diabetes. The TAFI antigen levels were determined in 50 patients with diabetic foot ulcers and 34 patients without diabetic foot ulcers and 25 healthy individuals. We measured TAFIa/ai antigen in plasma samples with a commercially available ELISA Kit. Diabetic foot ulcer group and diabetic group were similar in terms of mean age and sex distribution. Diabetes duration, retinopathy, neuropathy, macrovascular disease and infection were related to diabetic foot ulcers. HbA1c, HDL-cholesterol and Folic Acid levels were decreased in the diabetic foot ulcer group. TAFI levels were 99.44 ± 55.94% in control group, 135.21 ± 61.05% in diabetic foot ulcer group, 136.75 ± 59.38% in diabetic group and was statistically different (P < 0.05). But no difference was seen in TAFI levels between the diabetic foot ulcer group and diabetic group (P > 0.05). No significant difference in plasma TAFI levels were seen between diabetic foot ulcer stages. TAFI antigen levels are increased in Type 2 diabetic patients, but are not related to diabetic foot ulcer development.
血浆 TAFI 可能参与心血管疾病 (CVD) 中的动脉血栓形成，并且可能与糖尿病患者血管内皮损伤的机制有关。本研究旨在探讨 2 型糖尿病患者血浆 TAFI 抗原水平在糖尿病足溃疡发展中的相关性。测定了 50 例糖尿病足溃疡患者、34 例无糖尿病足溃疡患者和 25 例健康个体的血浆 TAFI 抗原水平。我们使用市售的 ELISA 试剂盒测定血浆中 TAFIa/ai 抗原。糖尿病足溃疡组和糖尿病组在年龄和性别分布方面相似。糖尿病病程、视网膜病变、神经病变、大血管疾病和感染与糖尿病足溃疡有关。糖尿病足溃疡组的 HbA1c、HDL-胆固醇和叶酸水平降低。对照组 TAFI 水平为 99.44 ± 55.94%，糖尿病足溃疡组为 135.21 ± 61.05%，糖尿病组为 136.75 ± 59.38%，差异有统计学意义 (P < 0.05)。但糖尿病足溃疡组与糖尿病组之间 TAFI 水平无差异 (P > 0.05)。糖尿病足溃疡各期之间 TAFI 水平无显著差异。2 型糖尿病患者血浆 TAFI 抗原水平升高，但与糖尿病足溃疡的发生无关。
