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血脂谱和载脂蛋白与糖尿病足溃疡风险的关系：系统评价和荟萃分析。

Association between Lipid Profile and Apolipoproteins with Risk of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis.

机构信息

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Sociedad Científica de Estudiantes de Medicina de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

出版信息

Int J Clin Pract. 2022 Aug 10;2022:5450173. doi: 10.1155/2022/5450173. eCollection 2022.

DOI:10.1155/2022/5450173
PMID:36016824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9385316/
Abstract

BACKGROUND AND AIMS

Biomarkers are necessary to stratify the risk of diabetic foot ulcers (DFUs). This systematic review and meta-analysis aimed to evaluate the association between the lipid profile and apolipoproteins with the risk of DFU.

METHODS

A systematic search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science among adult patients. Cohort and case-control studies were included. Random-effects models were used for meta-analyses, and the effects were expressed as odds ratio (OR) and their 95% confidence intervals (CIs). We evaluated publication bias through Egger's test and funnel plot.

RESULTS

A total of 12 cohort studies and 26 case-control studies were included, with 17076 patients. We found that the higher values of total cholesterol (TC), low-density lipoprotein (LDL), triglycerides, and lipoprotein(a) (Lp(a)) were associated with a higher risk of developing DFU (OR: 1.47, OR: 1.47, OR: 1.5, OR: 1.85, respectively). Otherwise, the lower values of HDL were associated with a higher risk of developing DFU (OR: 0.49). Publication bias was not found for associations between TC, HDL, LDL, or TG and the risk of DFU.

CONCLUSIONS

The high values of LDL, TC, TG, and Lp(a) and low values of HDL are associated with a higher risk of developing DFU. Furthermore, we did not find a significant association for VLDL, ApoA1, ApoB, and ApoB/ApoA1 ratio.

摘要

背景与目的

生物标志物对于糖尿病足溃疡（DFU）的风险分层是必要的。本系统评价和荟萃分析旨在评估血脂谱和载脂蛋白与 DFU 风险之间的关联。

方法

在 PubMed、Scopus、Cochrane 图书馆和 Web of Science 中对成年患者进行了系统搜索。纳入了队列研究和病例对照研究。使用随机效应模型进行荟萃分析，效应表示为比值比（OR）及其 95%置信区间（CI）。我们通过 Egger 检验和漏斗图评估发表偏倚。

结果

共纳入 12 项队列研究和 26 项病例对照研究，共 17076 名患者。我们发现总胆固醇（TC）、低密度脂蛋白（LDL）、甘油三酯和脂蛋白（a）（Lp（a））值越高，发生 DFU 的风险越高（OR：1.47，OR：1.47，OR：1.5，OR：1.85）。相反，高密度脂蛋白（HDL）值越低，发生 DFU 的风险越高（OR：0.49）。未发现 TC、HDL、LDL 或 TG 与 DFU 风险之间存在发表偏倚。

结论

LDL、TC、TG 和 Lp（a）值升高以及 HDL 值降低与发生 DFU 的风险增加相关。此外，我们未发现 VLDL、ApoA1、ApoB 和 ApoB/ApoA1 比值与 DFU 风险之间存在显著关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/c5cf745ce4b9/IJCLP2022-5450173.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/a19a78d941b2/IJCLP2022-5450173.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/a659bbdc3f0d/IJCLP2022-5450173.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/40760c927d59/IJCLP2022-5450173.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/ca45a956150b/IJCLP2022-5450173.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/c5cf745ce4b9/IJCLP2022-5450173.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/a19a78d941b2/IJCLP2022-5450173.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/a659bbdc3f0d/IJCLP2022-5450173.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/40760c927d59/IJCLP2022-5450173.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/ca45a956150b/IJCLP2022-5450173.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d83b/9385316/c5cf745ce4b9/IJCLP2022-5450173.005.jpg

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