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Transcriptional factor ENY2 promotes recruitment of the THO complex to the hsp70 gene of Drosophila melanogaster.

作者信息

Orlova A V, Kopytova D V, Krasnov A N, Nabirochkina E N, Ilyin Y V, Georgieva S G, Shidlovskii Yu V

机构信息

Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, Moscow, 119334, Russia.

出版信息

Dokl Biochem Biophys. 2010 Sep-Oct;434:227-31. doi: 10.1134/S1607672910050029. Epub 2010 Oct 20.

DOI:10.1134/S1607672910050029
PMID:20960243
Abstract
摘要

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Transcriptional factor ENY2 promotes recruitment of the THO complex to the hsp70 gene of Drosophila melanogaster.转录因子ENY2促进THO复合物募集至黑腹果蝇的hsp70基因。
Dokl Biochem Biophys. 2010 Sep-Oct;434:227-31. doi: 10.1134/S1607672910050029. Epub 2010 Oct 20.
2
Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA.多功能因子 ENY2 与 THO 复合物相关,并促进其招募到新生 mRNA 上。
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Involvement of general transcriptional factors in the regulation of transcription of the hsp70 gene in vivo.
Dokl Biol Sci. 2006 Nov-Dec;411:475-8. doi: 10.1134/s0012496606060147.
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Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.果蝇中受THO复合体调控的mRNA的全基因组分析。
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Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70.激活诱导多聚(ADP-核糖)聚合酶促进 HSP70 处核小体的丢失。
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The Role of Inducible Hsp70, and Other Heat Shock Proteins, in Adaptive Complex of Cold Tolerance of the Fruit Fly (Drosophila melanogaster).诱导型热休克蛋白70及其他热休克蛋白在果蝇(黑腹果蝇)耐寒适应性复合体中的作用
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Study of functional interaction between GAGA-containing sites from promoter regions of heat shock genes hsp26 and hsp70 in the model system of Drosophila melanogaster white gene.在果蝇白眼基因模型系统中对热休克基因hsp26和hsp70启动子区域含GAGA位点之间功能相互作用的研究。
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[Role of general transcription factors and the TFTC complex in transcription activation in vivo as revealed with a model of the hsp70 gene].[通过热休克蛋白70(hsp70)基因模型揭示通用转录因子和TFTC复合物在体内转录激活中的作用]
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[Multifunctional factor ENY2 integrates the various stages of gene expression].多功能因子ENY2整合基因表达的各个阶段
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Acta Naturae. 2018 Oct-Dec;10(4):110-114.
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Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A.一种天然萘丁烯酮——瓜兰烯 A 的细胞毒性、抗血管生成、凋亡作用及转录谱分析。
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本文引用的文献

1
Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.衔接蛋白Aly和共衔接蛋白Thoc5在Tap-p15介导的HSP70 mRNA核输出过程中发挥作用。
EMBO J. 2009 Mar 4;28(5):556-67. doi: 10.1038/emboj.2009.5. Epub 2009 Jan 22.
2
THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.THO/Sub2p的功能是协调3'末端加工与基因-核孔复合体的关联。
Cell. 2008 Oct 17;135(2):308-21. doi: 10.1016/j.cell.2008.08.005.
3
Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation.
THO/sub2突变体中的核mRNA监测是由低效的多聚腺苷酸化引发的。
Mol Cell. 2008 Jul 11;31(1):91-103. doi: 10.1016/j.molcel.2008.04.030.
4
SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC.SAGA和一种新型果蝇输出复合物将高效转录和mRNA输出锚定到核孔复合体。
EMBO J. 2007 Dec 12;26(24):4956-65. doi: 10.1038/sj.emboj.7601901. Epub 2007 Nov 22.
5
Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants.Tho1是一种新型异质性核糖核蛋白,Sub2为酵母THO突变体中的信使核糖核蛋白生物合成提供了替代途径。
Mol Cell Biol. 2006 Jun;26(12):4387-98. doi: 10.1128/MCB.00234-06.
6
Occupancy of the Drosophila hsp70 promoter by a subset of basal transcription factors diminishes upon transcriptional activation.果蝇hsp70启动子被一部分基础转录因子占据的情况在转录激活后会减少。
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18087-92. doi: 10.1073/pnas.0509063102. Epub 2005 Dec 5.
7
Recruitment of the human TREX complex to mRNA during splicing.剪接过程中人类 TREX 复合物与 mRNA 的结合。
Genes Dev. 2005 Jul 1;19(13):1512-7. doi: 10.1101/gad.1302205.
8
Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes.TREX复合物募集至无内含子和含内含子酵母基因的生化分析。
EMBO J. 2004 Jul 7;23(13):2620-31. doi: 10.1038/sj.emboj.7600261. Epub 2004 Jun 10.
9
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.果蝇中受THO复合体调控的mRNA的全基因组分析。
Nat Struct Mol Biol. 2004 Jun;11(6):558-66. doi: 10.1038/nsmb759. Epub 2004 May 9.
10
Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.稳定的mRNA核糖核蛋白(mRNP)形成和输出需要Hpr1p在转录过程中募集mRNA输出因子Yra1p和Sub2p。
Mol Cell Biol. 2002 Dec;22(23):8241-53. doi: 10.1128/MCB.22.23.8241-8253.2002.