Gurskiĭ D Ia, Orlova A V, Kopytova D V, Krasnov A N, Nabirochkina E N, Georgieva S G, Shidlovskiĭ Iu V
Genetika. 2010 Dec;46(12):1700-3.
The ENY2/Sus1 is a multifunctional transcription factor which couples transcription with mRNA export. It is the component of the SAGA/TFTC and TREX-2/AMEX protein complexes. Recently, we described the interaction of ENY2 with one more protein complex, THO. Moreover, our data indicate that ENY2 associates with other nuclear and cytoplasmic factors. Thus, being the component of a number of protein complexes, ENY2 plays the role of an adaptor molecule, involved into the integration of different cellular processes, specifically, subsequent stages of gene expression.
ENY2/Sus1是一种多功能转录因子，它将转录与mRNA输出联系起来。它是SAGA/TFTC和TREX-2/AMEX蛋白复合物的组成部分。最近，我们描述了ENY2与另一种蛋白复合物THO的相互作用。此外，我们的数据表明ENY2与其他核因子和细胞质因子相关联。因此，作为多种蛋白复合物的组成部分，ENY2起到衔接分子的作用，参与不同细胞过程的整合，特别是基因表达的后续阶段。
