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锌指蛋白CG9890——果蝇含ENY2复合体的新组分。

Zinc Finger Protein CG9890 - New Component of ENY2-Containing Complexes of Drosophila.

作者信息

Fursova N A, Nikolenko J V, Soshnikova N V, Mazina M Y, Vorobyova N E, Krasnov A N

机构信息

Institute of Gene Biology Russian Academy of Sciences, Vavilova Str., 34/5, Moscow, 119334, Russia.

出版信息

Acta Naturae. 2018 Oct-Dec;10(4):110-114.

PMID:30713769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6351030/
Abstract

In previous studies, we showed that the insulator protein Su(Hw) containing zinc finger domains interacts with the ENY2 protein and recruits the ENY2-containing complexes on Su(Hw)-dependent insulators, participating in the regulation of transcription and in the positioning of replication origins. Here, we found interaction between ENY2 and CG9890 protein, which also contains zinc finger domains. The interaction between ENY2 and CG9890 was confirmed. It was established that CG9890 protein is localized in the nucleus and interacts with the SAGA, ORC, dSWI/SNF, TFIID, and THO protein complexes.

摘要

在之前的研究中，我们发现含有锌指结构域的绝缘子蛋白Su(Hw)与ENY2蛋白相互作用，并在依赖于Su(Hw)的绝缘子上募集含ENY2的复合物，参与转录调控和复制起点的定位。在此，我们发现ENY2与同样含有锌指结构域的CG9890蛋白之间存在相互作用。ENY2与CG9890之间的相互作用得到了证实。已确定CG9890蛋白定位于细胞核，并与SAGA、ORC、dSWI/SNF、TFIID和THO蛋白复合物相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/bbf444f87d15/AN20758251-10-4-110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/6287dfa23093/AN20758251-10-4-110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/dc9e18a6aea2/AN20758251-10-4-110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/bbf444f87d15/AN20758251-10-4-110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/6287dfa23093/AN20758251-10-4-110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/dc9e18a6aea2/AN20758251-10-4-110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5270/6351030/bbf444f87d15/AN20758251-10-4-110-g003.jpg

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本文引用的文献

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Dokl Biochem Biophys. 2018 Mar;479(1):80-82. doi: 10.1134/S1607672918020059. Epub 2018 May 19.
2
Sharing the SAGA.分享传奇。
Trends Biochem Sci. 2017 Nov;42(11):850-861. doi: 10.1016/j.tibs.2017.09.001. Epub 2017 Sep 27.
3
C2H2 Zinc Finger Proteins: The Largest but Poorly Explored Family of Higher Eukaryotic Transcription Factors.
C2H2锌指蛋白：高等真核生物转录因子中最大但研究较少的家族。
Acta Naturae. 2017 Apr-Jun;9(2):47-58.
4
[SWI/SNF Protein Complexes Participate in the Initiation and Elongation Stages of Drosophila hsp70 Gene Transcription].[SWI/SNF蛋白复合物参与果蝇hsp70基因转录的起始和延伸阶段]
Genetika. 2016 Feb;52(2):164-9.
5
On the way of revealing coactivator complexes cross-talk during transcriptional activation.在揭示转录激活过程中辅激活因子复合物相互作用的道路上。
Cell Biosci. 2016 Feb 24;6:15. doi: 10.1186/s13578-016-0081-y. eCollection 2016.
6
Mechanisms and proteins involved in long-distance interactions.参与长距离相互作用的机制和蛋白质。
Front Genet. 2014 Feb 18;5:28. doi: 10.3389/fgene.2014.00028. eCollection 2014.
7
[Ability of Su(Hw) to create a platform for ORC binding does not depend on the type of surrounding chromatin].[Su(Hw) 创建 ORC 结合平台的能力不依赖于周围染色质的类型]
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8
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The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome.绝缘子蛋白 SU(HW) 精细调节果蝇基因组的核纤层相互作用。
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