Scott Brian A, Mortensen Joel E, McKeever Tricia M, Logas Dawn B, McKeever Patrick J
McKeever Dermatology Clinics, Eden Prairie, Minnesota 55344, USA.
Vet Ther. 2010 Fall;11(3):E1-7.
In the past 5 years, the incidence of canine skin infections caused by resistant strains of Staphylococcus (pseud)intermedius has increased. Many older antibiotics are used to treat these infections because the sensitivity can be demonstrated in vitro. Additionally, many of these older drugs are efficacious and unlikely to induce multidrug resistance. More than a decade ago, the antibiotic tylosin tartrate was reported to be efficacious in vitro and in vivo against Staphylococcus intermedius. The purpose of this study was to determine whether S. (pseud)intermedius isolated from untreated pyoderma cases at veterinary referral centers across the United States are sensitive in vitro to this antibiotic. Minimum inhibitory concentrations for tylosin tartrate and other commonly used antibiotics were determined for 103 isolates. Most (82.61%) of the isolates not exposed to antibiotics in the 3 months before submission were sensitive to tylosin tartrate. These findings suggest that tylosin tartrate warrants further study as a first-line option for the treatment of dogs initially presenting with pyoderma.
在过去5年中，由中间型葡萄球菌（类中间型葡萄球菌）耐药菌株引起的犬皮肤感染发病率有所上升。许多较老的抗生素被用于治疗这些感染，因为其敏感性可在体外得到证实。此外，许多这类较老的药物有效且不太可能诱导多药耐药性。十多年前，据报道抗生素酒石酸泰乐菌素在体外和体内对中间型葡萄球菌均有效。本研究的目的是确定从美国各地兽医转诊中心未经治疗的脓皮病病例中分离出的类中间型葡萄球菌在体外对这种抗生素是否敏感。对103株分离菌测定了酒石酸泰乐菌素和其他常用抗生素的最低抑菌浓度。在送检前3个月未接触过抗生素的分离菌中，大多数（82.61%）对酒石酸泰乐菌素敏感。这些发现表明，酒石酸泰乐菌素作为最初表现为脓皮病的犬的一线治疗选择值得进一步研究。
