Westermeyer Rebekah R, Roy Alma F, Mitchell Maria S, Merchant Sandra R
Veterinary Clinical Services, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA.
Vet Ther. 2010 Fall;11(3):E1-9.
The in vitro activity of 10 cephalosporin antimicrobial agents against 75 isolates of methicillin-susceptible Staphylococcus pseudintermedius derived from dogs was assessed. The lowest minimal inhibitory concentration for 90% of strains (MIC90) values obtained were for cephalothin, cefovecin, and cefazolin (0.12 ug/mL), followed by ceftiofur and cefoxitin (0.25 ug/mL), cefpodoxime (0.5 ug/mL), and cefaclor and cefadroxil (1 ug/mL). The highest MIC90 values were found for cephalexin and cefixime (2 ug/mL). In this in vitro study, sensitivity to cephalothin was indicative of cephalexin susceptibility, although there were marked differences in MICs. Cephalothin susceptibility was not indicative of susceptibility to all tested cephalosporins, nor was there a clear trend in susceptibility based on cephalosporin generation.
评估了10种头孢菌素抗菌剂对75株从犬类分离出的甲氧西林敏感中间型葡萄球菌的体外活性。所获得的90%菌株的最低抑菌浓度（MIC90）值中，头孢噻吩、头孢维星和头孢唑林最低（0.12微克/毫升），其次是头孢噻呋和头孢西丁（0.25微克/毫升）、头孢泊肟（0.5微克/毫升）以及头孢克洛和头孢羟氨苄（1微克/毫升）。头孢氨苄和头孢克肟的MIC90值最高（2微克/毫升）。在这项体外研究中，对头孢噻吩的敏感性表明对头孢氨苄敏感，尽管MICs存在显著差异。头孢噻吩敏感性并不表明对所有测试头孢菌素敏感，基于头孢菌素代也没有明显的敏感性趋势。
